Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TOP1 | P11387 | 1/20 | 0.41 |
| ▸ | TAAR1 | Q96RJ0 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 5/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 5/20 | 0.40 |
| ▸ | ERN1 | O75460 | 2/20 | 0.38 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 3/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 3/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.35 |
| ▸ | PKM | P14618 | 3/20 | 0.35 |
| ▸ | POLB | P06746 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | HPGD | P15428 | 2/20 | 0.35 |
| ▸ | RECQL | P46063 | 2/20 | 0.35 |
| ▸ | BLM | P54132 | 2/20 | 0.35 |
| ▸ | RAB9A | P51151 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6193416 | 0.82 | ERN1 (0.49) | TOP1TAAR1MAPTHSD17B10ERN1 | |
| SCHEMBL18876366 | 0.74 | TOP1 (0.42) | TOP1TAAR1MAPTHSD17B10ERN1 | |
| SCHEMBL28195936 | 0.74 | TAAR1 (0.52) | TOP1TAAR1MAPTHSD17B10KEAP1 | |
| SCHEMBL18876368 | 0.74 | TOP1 (0.42) | TOP1TAAR1MAPTHSD17B10ERN1 | |
| SCHEMBL18876434 | 0.71 | TAAR1 (0.41) | TOP1TAAR1MAPTHSD17B10ERN1 | |
| SCHEMBL7013818 | 0.71 | PIK3CA (0.47) | MAPTHSD17B10ALDH1A1ALOX15TDP1 | |
| SCHEMBL8445207 | 0.71 | HDAC6 (0.41) | MAPTALDH1A1KDM4ESMN1; SMN2MEN1 | |
| SCHEMBL18879698 | 0.70 | TOP1 (0.40) | TOP1TAAR1MAPTHSD17B10ERN1 | |
| SCHEMBL27624181 | 0.70 | KEAP1 (0.46) | TOP1TAAR1MAPTHSD17B10ERN1 | |
| SCHEMBL19662062 | 0.69 | TAAR1 (0.58) | TOP1TAAR1MAPTHSD17B10ERN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1349861-A1 | THIENO(3,2-d)PYRIMIDINES AND FURANO(3,2-d)PYRIMIDINES AND THEIR USE AS PURINERGIC RECEPTOR ANTAGONISTS | VERNALIS RESEARCH LIMITED (GB) | 2003-10-08 | — | — | EP | disclosed |
| WO-2002055524-A1 | THIENO(3,2-d)PYRIMIDINES AND FURANO(3,2-d)PYRIMIDINES AND THEIR USE AS PURINERGIC RECEPTOR ANTAGONISTS | VERNALIS RESEARCH LIMITED (GB) | 2002-07-18 | — | — | WO | disclosed |