Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LCK | P06239 | 9/20 | 0.43 |
| ▸ | CDK2 | P24941 | 1/20 | 0.38 |
| ▸ | MKNK2 | Q9HBH9 | 7/20 | 0.37 |
| ▸ | MKNK1 | Q9BUB5 | 7/20 | 0.37 |
| ▸ | MAP3K14 | Q99558 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7018022 | 0.96 | LCK (0.43) | LCKCDK2MKNK2MKNK1MAP3K14 | |
| SCHEMBL7020602 | 0.81 | MKNK1 (0.38) | LCKCDK2MKNK2MKNK1 | |
| SCHEMBL7017717 | 0.81 | MAP3K14 (0.38) | LCKCDK2MKNK2MKNK1MAP3K14 | |
| SCHEMBL7016354 | 0.75 | MKNK1 (0.35) | LCKCDK2MKNK2MKNK1MAP3K14 | |
| SCHEMBL7018014 | 0.72 | MKNK2 (0.60) | LCKMKNK2MKNK1 | |
| SCHEMBL7585859 | 0.69 | LCK (0.84) | LCKMKNK2MKNK1 | |
| SCHEMBL7018013 | 0.69 | LCK (0.84) | LCKMKNK2MKNK1 | |
| SCHEMBL7018020 | 0.69 | MKNK2 (0.60) | LCKMKNK2MKNK1 | |
| SCHEMBL7590066 | 0.66 | LCK (0.84) | LCKMKNK2MKNK1 | |
| SCHEMBL7018018 | 0.66 | LCK (0.84) | LCKMKNK2MKNK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1206265-B1 | SRC KINASE INHIBITOR COMPOUNDS | MERCK & CO INC (US) | 2003-11-12 | — | — | EP | disclosed |
| US-6498165-B1 | PYRIMIDINE COMPOUNDS; PROPHYLAXIS AND TREATMENT OF SUCH AS IMMUNE DISEASES, HYPERPROLIFERATIVE DISORDERS, CANCER, ANGIOGENSIS, ATHEROSCELEROSIS, GRAFT REJECTION, RHEUMATOID ARTHRITIS, PSORIASIS | MERCK & CO., INC. | 2002-12-24 | — | — | US | disclosed |