Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE5A | O76074 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 3/20 | 0.41 |
| ▸ | NPC1 | O15118 | 2/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | CSNK2A1 | P68400 | 2/20 | 0.39 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.39 |
| ▸ | CSNK2B | P67870 | 1/20 | 0.39 |
| ▸ | ATG4B | Q9Y4P1 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.38 |
| ▸ | ACHE | P22303 | 4/20 | 0.37 |
| ▸ | APP | P05067 | 2/20 | 0.37 |
| ▸ | BCHE | P06276 | 2/20 | 0.37 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.36 |
| ▸ | PRKCQ | Q04759 | 1/20 | 0.36 |
| ▸ | PKM | P14618 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.36 |
| ▸ | CDK2 | P24941 | 1/20 | 0.36 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bicarbonate SCHEMBL7013221 | 0.91 | PDE5A (0.55) | PDE5AMAPTATG4BKMT2AACHE | |
| SCHEMBL8185665 | 0.90 | MAPT (0.40) | MAPTNPC1RAB9ACSNK2A1CSNK2A2 | |
| SCHEMBL7427837 | 0.88 | PDE5A (0.58) | PDE5AMAPTKMT2AACHEAPP | |
| Bicarbonate SCHEMBL7010933 | 0.87 | KDM4E (0.46) | MAPTNPC1RAB9AKMT2AMEN1 | |
| Bicarbonate SCHEMBL7014883 | 0.85 | PDE5A (0.46) | PDE5AMAPTKMT2AMEN1L3MBTL1 | |
| Bicarbonate SCHEMBL7018200 | 0.85 | PDE5A (0.47) | PDE5ANPC1CSNK2A1CSNK2A2CSNK2B | |
| Bicarbonate SCHEMBL7017937 | 0.85 | PDE5A (0.47) | PDE5ANPC1RAB9ACSNK2A1CSNK2A2 | |
| Bicarbonate SCHEMBL7014406 | 0.83 | KDM4E (0.48) | PDE5ACSNK2A1CSNK2A2CSNK2BKMT2A | |
| Bicarbonate SCHEMBL7021236 | 0.83 | PDE5A (0.45) | PDE5ARAB9AATG4BPRKCQHTT | |
| Bicarbonate SCHEMBL7016966 | 0.83 | PDE5A (0.44) | PDE5AMAPTNPC1RAB9ACSNK2A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0934321-B1 | THIENOPYRIMIDINE WITH PHOSPHODIESTERASE V INHIBITING EFFECT | MERCK PATENT GMBH (DE) | 2003-08-06 | — | — | EP | disclosed |