Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE5A | O76074 | 15/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7422776 | 0.95 | CCR4 (0.42) | PDE5A | |
| SCHEMBL7010792 | 0.94 | PDE5A (0.47) | PDE5A | |
| SCHEMBL7016974 | 0.93 | PDE5A (0.46) | PDE5A | |
| SCHEMBL7016678 | 0.92 | PDE4A (0.40) | PDE5A | |
| SCHEMBL7018309 | 0.91 | PDE5A (0.46) | PDE5A | |
| SCHEMBL7019437 | 0.91 | PDE5A (0.49) | PDE5A | |
| SCHEMBL7015126 | 0.90 | PDE5A (0.47) | PDE5A | |
| SCHEMBL8170057 | 0.89 | PDE5A (0.48) | PDE5A | |
| SCHEMBL7016980 | 0.88 | CTNNB1 (0.48) | — | |
| SCHEMBL7017144 | 0.88 | HRH4 (0.45) | PDE5A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0934321-B1 | THIENOPYRIMIDINE WITH PHOSPHODIESTERASE V INHIBITING EFFECT | MERCK PATENT GMBH (DE) | 2003-08-06 | — | — | EP | disclosed |
| EP-0934321-A1 | THIENOPYRIMIDINE WITH PHOSPHODIESTERASE V INHIBITING EFFECT | MERCK PATENT GmbH (DE) | 1999-08-11 | — | — | EP | disclosed |
| WO-1998017668-A1 | THIENOPYRIMIDINE WITH PHOSPHODIESTERASE V INHIBITING EFFECT | MERCK PATENT GMBH (DE) | 1998-04-30 | — | — | WO | disclosed |