Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR4 | P51679 | 1/20 | 0.42 |
| ▸ | PDE5A | O76074 | 11/20 | 0.41 |
| ▸ | APP | P05067 | 3/20 | 0.40 |
| ▸ | ACHE | P22303 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | PDE4A | P27815 | 1/20 | 0.38 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.38 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.38 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.38 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7018705 | 0.95 | PDE5A (0.47) | PDE5A | |
| SCHEMBL7014745 | 0.92 | APP (0.41) | CCR4PDE5AAPPACHETP53 | |
| SCHEMBL7016913 | 0.91 | APP (0.40) | CCR4PDE5AAPPACHETP53 | |
| SCHEMBL7011635 | 0.91 | CCR4 (0.44) | CCR4PDE5AAPPACHETP53 | |
| SCHEMBL7016678 | 0.90 | PDE4A (0.40) | PDE5APDE4APDE4BPDE4CPDE4D | |
| SCHEMBL7013933 | 0.90 | APP (0.39) | CCR4PDE5AAPPACHETP53 | |
| SCHEMBL8181123 | 0.89 | ALDH1A1 (0.49) | CCR4PDE5ATP53PDE4APDE4B | |
| SCHEMBL7016980 | 0.89 | CTNNB1 (0.48) | HRH4 | |
| SCHEMBL7010792 | 0.89 | PDE5A (0.47) | PDE5A | |
| SCHEMBL7019169 | 0.88 | PDE5A (0.39) | CCR4PDE5AAPPACHETP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0934321-A1 | THIENOPYRIMIDINE WITH PHOSPHODIESTERASE V INHIBITING EFFECT | MERCK PATENT GmbH (DE) | 1999-08-11 | — | — | EP | disclosed |
| WO-1998017668-A1 | THIENOPYRIMIDINE WITH PHOSPHODIESTERASE V INHIBITING EFFECT | MERCK PATENT GMBH (DE) | 1998-04-30 | — | — | WO | disclosed |