Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE5A | O76074 | 13/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7016510 | 0.93 | TP53 (0.40) | PDE5A | |
| SCHEMBL7012518 | 0.93 | ESR1 (0.42) | PDE5A | |
| SCHEMBL7015450 | 0.92 | PDE5A (0.48) | PDE5A | |
| SCHEMBL8169967 | 0.90 | PDE5A (0.47) | PDE5A | |
| SCHEMBL7017441 | 0.88 | PDE5A (0.46) | PDE5A | |
| SCHEMBL7017615 | 0.88 | PDE5A (0.46) | PDE5A | |
| SCHEMBL7011555 | 0.87 | PDE5A (0.44) | PDE5A | |
| SCHEMBL8185408 | 0.87 | PDE5A (0.52) | PDE5A | |
| SCHEMBL7011880 | 0.86 | CTNNB1 (0.45) | — | |
| SCHEMBL7010792 | 0.86 | PDE5A (0.47) | PDE5A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0934321-B1 | THIENOPYRIMIDINE WITH PHOSPHODIESTERASE V INHIBITING EFFECT | MERCK PATENT GMBH (DE) | 2003-08-06 | — | — | EP | disclosed |