Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE5A | O76074 | 14/20 | 0.52 |
| ▸ | PDE4A | P27815 | 1/20 | 0.46 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.46 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.46 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8183548 | 0.93 | PDE4A (0.44) | PDE5APDE4APDE4BPDE4CPDE4D | |
| SCHEMBL8169967 | 0.92 | PDE5A (0.47) | PDE5A | |
| SCHEMBL8171364 | 0.91 | PDE4A (0.49) | PDE5APDE4APDE4BPDE4CPDE4D | |
| SCHEMBL7015450 | 0.91 | PDE5A (0.48) | PDE5A | |
| SCHEMBL8170609 | 0.87 | PDE5A (0.52) | PDE5APDE4APDE4BPDE4CPDE4D | |
| SCHEMBL8181196 | 0.87 | PDE5A (0.52) | PDE5APDE4APDE4BPDE4CPDE4D | |
| SCHEMBL7018914 | 0.87 | PDE5A (0.46) | PDE5A | |
| SCHEMBL8184351 | 0.85 | PDE5A (0.45) | PDE5A | |
| SCHEMBL8177973 | 0.85 | PDE5A (0.51) | PDE5APDE4APDE4BPDE4CPDE4D | |
| SCHEMBL8184555 | 0.85 | PDE5A (0.55) | PDE5APDE4APDE4BPDE4CPDE4D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6130223-A | Thienopyrimidine with phosphodiesterase V inhibiting effect | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 2000-10-10 | — | — | US | disclosed |