Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE known ✓ | P22303 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.51 |
| ▸ | POLB | P06746 | 2/20 | 0.48 |
| ▸ | LMNA | P02545 | 3/20 | 0.46 |
| ▸ | HSP90AA1 | P07900 | 4/20 | 0.45 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | BACE1 | P56817 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7019932 | 0.99 | KMT2A (0.49) | KMT2AL3MBTL1ALDH1A1MAPK1POLB | |
| Hydrochloric Acid SCHEMBL7028394 | 0.90 | KMT2A (0.57) | KMT2AL3MBTL1ALDH1A1MAPK1POLB | |
| SCHEMBL7022552 | 0.88 | KMT2A (0.55) | KMT2AL3MBTL1ALDH1A1MAPK1POLB | |
| Hydrochloric Acid SCHEMBL7028355 | 0.84 | KMT2A (0.51) | KMT2AL3MBTL1ALDH1A1MAPK1POLB | |
| Hydrochloric Acid SCHEMBL7026394 | 0.84 | KMT2A (0.51) | KMT2AL3MBTL1ALDH1A1MAPK1POLB | |
| SCHEMBL7022333 | 0.82 | KMT2A (0.49) | KMT2AL3MBTL1ALDH1A1MAPK1POLB | |
| SCHEMBL7024970 | 0.82 | KMT2A (0.49) | KMT2AL3MBTL1ALDH1A1MAPK1POLB | |
| Hydrochloric Acid SCHEMBL7018300 | 0.82 | POLB (0.55) | KMT2AL3MBTL1ALDH1A1MAPK1POLB | |
| Hydrochloric Acid SCHEMBL7026792 | 0.82 | POLB (0.55) | KMT2AL3MBTL1ALDH1A1MAPK1POLB | |
| Hydrochloric Acid SCHEMBL6943270 | 0.82 | KMT2A (0.68) | KMT2AL3MBTL1ALDH1A1MAPK1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1066246-B1 | NOVEL CATIONIC COUPLERS AND THEIR USE FOR OXIDATION DYEING | OREAL (FR) | 2003-11-05 | — | — | EP | claimed |
| US-6605124-B1 | Naphthol hair dyes for keratinous fibers | L'OREAL S.A. (FR) | 2003-08-12 | — | — | US | claimed |
| US-6605124-B1 | Naphthol hair dyes for keratinous fibers | L'OREAL S.A. (FR) | 2003-08-12 | — | — | US | disclosed |