Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 5/20 | 0.54 |
| ▸ | SCN9A | Q15858 | 5/20 | 0.54 |
| ▸ | SCN5A | Q14524 | 4/20 | 0.54 |
| ▸ | MTNR1A | P48039 | 6/20 | 0.50 |
| ▸ | MTNR1B | P49286 | 6/20 | 0.50 |
| ▸ | DRD4 | P21917 | 2/20 | 0.42 |
| ▸ | DRD2 | P14416 | 2/20 | 0.42 |
| ▸ | MLYCD | O95822 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | HTR2A | P28223 | 1/20 | 0.40 |
| ▸ | DRD3 | P35462 | 1/20 | 0.40 |
| ▸ | SLC6A5 | Q9Y345 | 1/20 | 0.39 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.39 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7029805 | 1.00 | KCNH2 (0.54) | KCNH2SCN9ASCN5AMTNR1AMTNR1B | |
| SCHEMBL6820338 | 0.91 | KCNH2 (0.55) | KCNH2SCN9ASCN5AMTNR1AMTNR1B | |
| SCHEMBL6820334 | 0.91 | KCNH2 (0.55) | KCNH2SCN9ASCN5AMTNR1AMTNR1B | |
| SCHEMBL7025761 | 0.91 | KCNH2 (0.55) | KCNH2SCN9ASCN5AMTNR1AMTNR1B | |
| SCHEMBL7023472 | 0.89 | MTNR1A (0.55) | KCNH2SCN9ASCN5AMTNR1AMTNR1B | |
| SCHEMBL7030289 | 0.89 | MTNR1A (0.55) | KCNH2SCN9ASCN5AMTNR1AMTNR1B | |
| SCHEMBL7030407 | 0.88 | MTNR1A (0.54) | KCNH2SCN9ASCN5AMTNR1AMTNR1B | |
| SCHEMBL7030412 | 0.88 | MTNR1A (0.54) | KCNH2SCN9ASCN5AMTNR1AMTNR1B | |
| SCHEMBL7027930 | 0.87 | MTNR1A (0.65) | KCNH2SCN9ASCN5AMTNR1AMTNR1B | |
| SCHEMBL7027929 | 0.87 | MTNR1A (0.65) | KCNH2SCN9ASCN5AMTNR1AMTNR1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0888319-B1 | SUBSTITUTED 1,2,3,4-TETRAHYDRONAPHTHALENE DERIVATIVES | ASTRAZENECA AB (SE) | 2003-01-29 | — | — | EP | claimed |
| US-6124283-A | Substituted 1,2,3,4-tetrahydronaphthalene derivatives | ASTRA AKTIEBOLAG (SE) | 2000-09-26 | — | — | US | claimed |
| EP-0888319-B1 | SUBSTITUTED 1,2,3,4-TETRAHYDRONAPHTHALENE DERIVATIVES | ASTRAZENECA AB (SE) | 2003-01-29 | — | — | EP | disclosed |
| US-6410530-B1 | CENTRAL NERVOUS SYSTEM DISORDERS; PSYCHOLOGICAL DISORDERS | ASTRAZENECA AB (SE) | 2002-06-25 | — | — | US | disclosed |
| US-6124283-A | Substituted 1,2,3,4-tetrahydronaphthalene derivatives | ASTRA AKTIEBOLAG (SE) | 2000-09-26 | — | — | US | disclosed |