Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX15 | P16050 | 2/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | PGR | P06401 | 1/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.31 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.31 |
| ▸ | MAOA | P21397 | 1/20 | 0.31 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
| ▸ | AVPR2 | P30518 | 1/20 | 0.31 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.31 |
| ▸ | HTR2B | P41595 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.31 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.31 |
| ▸ | SLC29A1 | Q99808 | 1/20 | 0.31 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.31 |
| ▸ | APEX1 | P27695 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7032327 | 0.84 | ALOX15 (0.33) | ALOX15TBXA2R | |
| SCHEMBL7659952 | 0.78 | PTPN1 (0.32) | — | |
| SCHEMBL7023407 | 0.78 | ALOX15 (0.33) | ALOX15MAPTTBXA2RTDP1 | |
| SCHEMBL13937723 | 0.78 | HMGCR (0.41) | CYP2D6TBXA2RCYP2C19TDP1 | |
| SCHEMBL7029925 | 0.74 | APEX1 (0.41) | LMNAPGRCYP3A4CYP2D6MAPT | |
| SCHEMBL7025249 | 0.72 | CYP2C19 (0.35) | ALOX15CYP3A4CYP2D6CYP2C9TBXA2R | |
| SCHEMBL7655800 | 0.70 | PTPN1 (0.33) | ALOX15 | |
| SCHEMBL7033924 | 0.70 | HMGCR (0.31) | CYP2D6TBXA2RCYP2C19 | |
| SCHEMBL7032917 | 0.69 | CYP2C19 (0.39) | ALOX15CYP3A4CYP2D6CYP2C9TBXA2R | |
| SCHEMBL16858347 | 0.68 | HPGD (0.39) | MAPTCYP2C9CYP2C19HTTTDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1064253-B1 | ANTI-TUMOUR AGENTS | ASTRAZENECA AB (SE) | 2003-01-29 | — | — | EP | claimed |
| EP-1064253-B1 | ANTI-TUMOUR AGENTS | ASTRAZENECA AB (SE) | 2003-01-29 | — | — | EP | disclosed |
| US-6346633-B1 | TERT-AMINOPHENYLESTER OF ACID | ASTRAZENECA AB (SE) | 2002-02-12 | — | — | US | disclosed |