Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SRC | P12931 | 13/20 | 0.66 |
| ▸ | EGFR | P00533 | 12/20 | 0.64 |
| ▸ | ABL1 | P00519 | 10/20 | 0.64 |
| ▸ | ABL2 | P42684 | 9/20 | 0.64 |
| ▸ | LCK | P06239 | 8/20 | 0.62 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.61 |
| ▸ | HCK | P08631 | 3/20 | 0.58 |
| ▸ | BTK | Q06187 | 4/20 | 0.57 |
| ▸ | TEK | Q02763 | 5/20 | 0.56 |
| ▸ | KDR | P35968 | 3/20 | 0.56 |
| ▸ | FYN | P06241 | 2/20 | 0.56 |
| ▸ | LYN | P07948 | 2/20 | 0.56 |
| ▸ | CSK | P41240 | 2/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.56 |
| ▸ | MEN1 | O00255 | 1/20 | 0.56 |
| ▸ | RGS12 | O14924 | 1/20 | 0.56 |
| ▸ | NPC1 | O15118 | 1/20 | 0.56 |
| ▸ | GMNN | O75496 | 1/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.56 |
| ▸ | LMNA | P02545 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7017312 | 0.91 | SRC (0.65) | SRCEGFRABL1ABL2LCK | |
| SCHEMBL7015822 | 0.89 | ABL1 (0.77) | SRCEGFRABL1ABL2LCK | |
| SCHEMBL7017930 | 0.89 | SRC (0.68) | SRCEGFRABL1ABL2LCK | |
| SCHEMBL7019170 | 0.88 | EGFR (0.79) | SRCEGFRABL1ABL2LCK | |
| SCHEMBL22845563 | 0.86 | HCK (0.80) | SRCEGFRABL1LCKHCK | |
| SCHEMBL22845296 | 0.86 | HCK (0.80) | SRCEGFRABL1LCKHCK | |
| SCHEMBL7020164 | 0.86 | SRC (0.81) | SRCEGFRABL1ABL2LCK | |
| SCHEMBL22835091 | 0.86 | HCK (0.79) | SRCEGFRABL1LCKHCK | |
| SCHEMBL22845273 | 0.86 | HCK (0.79) | SRCEGFRABL1LCKHCK | |
| SCHEMBL22845272 | 0.86 | HCK (0.79) | SRCEGFRABL1LCKHCK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0888353-B1 | N-7-HETEROCYCLYL PYRROLO [2,3-d]PYRIMIDINES AND THEIR USE | NOVARTIS AG (CH) | 2003-07-09 | — | — | EP | claimed |
| EP-0888353-B1 | N-7-HETEROCYCLYL PYRROLO [2,3-d]PYRIMIDINES AND THEIR USE | NOVARTIS AG (CH) | 2003-07-09 | — | — | EP | disclosed |
| US-6051577-A | TYROSINE INHIBITORS; BONE DISORDERS | NOVARTIS AG (CH) | 2000-04-18 | — | — | US | disclosed |