Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SRC | P12931 | 16/20 | 0.81 |
| ▸ | EGFR | P00533 | 13/20 | 0.81 |
| ▸ | ABL1 | P00519 | 11/20 | 0.81 |
| ▸ | ABL2 | P42684 | 11/20 | 0.81 |
| ▸ | LCK | P06239 | 4/20 | 0.81 |
| ▸ | HCK | P08631 | 1/20 | 0.72 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.69 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.60 |
| ▸ | MEN1 | O00255 | 1/20 | 0.60 |
| ▸ | RGS12 | O14924 | 1/20 | 0.60 |
| ▸ | NPC1 | O15118 | 1/20 | 0.60 |
| ▸ | GMNN | O75496 | 1/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.60 |
| ▸ | LMNA | P02545 | 1/20 | 0.60 |
| ▸ | TP53 | P04637 | 1/20 | 0.60 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.60 |
| ▸ | FYN | P06241 | 1/20 | 0.60 |
| ▸ | LYN | P07948 | 1/20 | 0.60 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.60 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7023713 | 0.94 | SRC (0.72) | SRCEGFRABL1ABL2LCK | |
| SCHEMBL8107249 | 0.90 | SRC (0.80) | SRCEGFRABL1ABL2LCK | |
| SCHEMBL8108556 | 0.90 | ABL1 (1.00) | SRCEGFRABL1ABL2LCK | |
| SCHEMBL8114235 | 0.89 | SRC (0.71) | SRCEGFRABL1ABL2LCK | |
| SCHEMBL17749169 | 0.89 | SRC (0.75) | SRCEGFRABL1ABL2LCK | |
| SCHEMBL21283026 | 0.88 | HCK (0.90) | SRCEGFRABL1ABL2LCK | |
| SCHEMBL7019630 | 0.87 | SRC (0.81) | SRCEGFRABL1ABL2LCK | |
| SCHEMBL7021384 | 0.87 | EGFR (1.00) | SRCEGFRABL1ABL2LCK | |
| SCHEMBL8320799 | 0.86 | SRC (0.81) | SRCEGFRABL1ABL2LCK | |
| SCHEMBL7019209 | 0.86 | SRC (0.66) | SRCEGFRABL1ABL2LCK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0888353-B1 | N-7-HETEROCYCLYL PYRROLO [2,3-d]PYRIMIDINES AND THEIR USE | NOVARTIS AG (CH) | 2003-07-09 | — | — | EP | disclosed |
| CN-1079796-C | Novel N-7-heterocyclyl-pyrrolo [2, 3-d ] pyrimidines and their use | NOVARTIS AG (CH) | 2002-02-27 | — | — | CN | disclosed |
| US-6051577-A | TYROSINE INHIBITORS; BONE DISORDERS | NOVARTIS AG (CH) | 2000-04-18 | — | — | US | disclosed |
| CN-1216544-A | Novel N-7-heterocyclyl pyrrolo [2,3-D] pyridines and their use | NOVARTIS AG (CH) | 1999-05-12 | — | — | CN | disclosed |