Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.47 |
| ▸ | MAPT | P10636 | 4/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 2/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | PDE5A | O76074 | 4/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5413011 | 0.91 | ALDH1A1 (0.46) | HSD17B10ALDH1A1KDM4EMAPTHTT | |
| SCHEMBL5417552 | 0.90 | KDM4E (0.49) | HSD17B10ALDH1A1KDM4EMAPTHTT | |
| SCHEMBL5419673 | 0.84 | ALDH1A1 (0.49) | HSD17B10ALDH1A1KDM4EMAPTHTT | |
| SCHEMBL5409577 | 0.82 | MAPT (0.44) | HSD17B10ALDH1A1KDM4EMAPTHTT | |
| SCHEMBL5410532 | 0.81 | MAPT (0.46) | HSD17B10ALDH1A1KDM4EMAPTHTT | |
| SCHEMBL5402116 | 0.79 | MAPT (0.47) | HSD17B10ALDH1A1KDM4EMAPTHTT | |
| SCHEMBL5408430 | 0.79 | ALDH1A1 (0.47) | HSD17B10ALDH1A1KDM4EMAPTHTT | |
| SCHEMBL5412985 | 0.79 | PDE5A (0.49) | HSD17B10ALDH1A1KDM4EMAPTHTT | |
| SCHEMBL5412840 | 0.78 | MAPT (0.46) | HSD17B10ALDH1A1KDM4EMAPTHTT | |
| SCHEMBL7016071 | 0.78 | SMN1; SMN2 (0.42) | HSD17B10ALDH1A1KDM4EMAPTHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1294729-A1 | 2-AMINOALKYL-THIENO[2,3-D]PYRIMIDINES | MERCK PATENT GmbH (DE) | 2003-03-26 | — | — | EP | disclosed |
| WO-2002000664-A1 | 2-AMINOALKYL-THIENO[2,3-D]PYRIMIDINES | MERCK PATENT GMBH (DE) | 2002-01-03 | — | — | WO | disclosed |