Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 1/20 | 0.31 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.31 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.31 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.31 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7019572 | 1.00 | PDE4A (0.31) | PDE4AADORA2APDE4BPDE4CPDE4D | |
| SCHEMBL7016851 | 0.87 | ADORA2A (0.33) | PDE4AADORA2APDE4BPDE4CPDE4D | |
| SCHEMBL7016847 | 0.87 | ADORA2A (0.33) | PDE4AADORA2APDE4BPDE4CPDE4D | |
| SCHEMBL7027036 | 0.78 | ADORA3 (0.37) | PDE4AADORA2APDE4BPDE4CPDE4D | |
| SCHEMBL7027041 | 0.78 | ADORA3 (0.37) | PDE4AADORA2APDE4BPDE4CPDE4D | |
| SCHEMBL7015737 | 0.77 | FEN1 (0.50) | — | |
| SCHEMBL7015733 | 0.77 | FEN1 (0.50) | — | |
| SCHEMBL7098322 | 0.76 | FEN1 (0.32) | — | |
| SCHEMBL7018089 | 0.75 | KDM4E (0.43) | PDE4AADORA2APDE4BPDE4CPDE4D | |
| SCHEMBL7018087 | 0.75 | KDM4E (0.43) | PDE4AADORA2APDE4BPDE4CPDE4D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1357114-A1 | Substituted pyrimidin-2,4(1H,3H)-diones as inhibitors of Matrix Metalloproteinases (MMP) | IBFB GmbH Privates Institut für biomedizinische Forschung und Beratung (DE) | 2003-10-29 | — | — | EP | claimed |
| EP-1357114-A1 | Substituted pyrimidin-2,4(1H,3H)-diones as inhibitors of Matrix Metalloproteinases (MMP) | IBFB GmbH Privates Institut für biomedizinische Forschung und Beratung (DE) | 2003-10-29 | — | — | EP | disclosed |