Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CAMKK2 | Q96RR4 | 6/20 | 0.47 |
| ▸ | MAPK8 | P45983 | 4/20 | 0.47 |
| ▸ | PIK3CG | P48736 | 3/20 | 0.47 |
| ▸ | GSK3B | P49841 | 3/20 | 0.47 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.41 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.40 |
| ▸ | IKBKB | O14920 | 1/20 | 0.37 |
| ▸ | PIM1 | P11309 | 1/20 | 0.36 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.36 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.35 |
| ▸ | MET | P08581 | 1/20 | 0.35 |
| ▸ | CHEK2 | O96017 | 2/20 | 0.35 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.35 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.34 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.34 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.34 |
| ▸ | EGFR | P00533 | 1/20 | 0.34 |
| ▸ | SYK | P43405 | 1/20 | 0.34 |
| ▸ | CLK1 | P49759 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5094646 | 0.88 | MAPK8 (0.42) | CAMKK2MAPK8PIK3CGGSK3BMAPK10 | |
| SCHEMBL5093665 | 0.85 | CAMKK2 (0.62) | CAMKK2MAPK8PIK3CGGSK3BMAPK10 | |
| SCHEMBL5094187 | 0.81 | CAMKK2 (0.48) | CAMKK2MAPK8PIK3CGGSK3BMAPK10 | |
| SCHEMBL5089409 | 0.80 | MAPK8 (0.54) | CAMKK2MAPK8PIK3CGGSK3BMAPK10 | |
| SCHEMBL5989559 | 0.80 | CAMKK2 (0.46) | CAMKK2MAPK8PIK3CGGSK3BMAPK10 | |
| SCHEMBL5089550 | 0.78 | MAPK8 (0.58) | CAMKK2MAPK8PIK3CGGSK3BMAPK10 | |
| SCHEMBL5089098 | 0.78 | PIM1 (0.38) | PIK3CGIKBKBPIM1PIM2DYRK1B | |
| SCHEMBL5092372 | 0.76 | CAMKK2 (0.54) | CAMKK2MAPK8PIK3CGGSK3BMAPK10 | |
| SCHEMBL5091989 | 0.76 | MAPK8 (0.59) | CAMKK2MAPK8PIK3CGGSK3BMAPK10 | |
| SCHEMBL5093661 | 0.75 | CAMKK2 (0.49) | CAMKK2MAPK8PIK3CGGSK3BMAPK10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1317433-A2 | INHIBITORS OF GLYCOGEN SYNTHASE KINASE 3 | CHIRON CORPORATION (US) | 2003-06-11 | — | — | EP | disclosed |
| WO-2002020495-A2 | INHIBITORS OF GLYCOGEN SYNTHASE KINASE 3 | CHIRON CORPORATION (US) | 2002-03-14 | — | — | WO | disclosed |