Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 10/20 | 0.60 |
| ▸ | PDE4B | Q07343 | 10/20 | 0.60 |
| ▸ | PDE4C | Q08493 | 10/20 | 0.60 |
| ▸ | PDE4D | Q08499 | 10/20 | 0.60 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.31 |
| ▸ | SLC22A12 | Q96S37 | 2/20 | 0.31 |
| ▸ | PIK3C3 | Q8NEB9 | 2/20 | 0.30 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | TSHR | P16473 | 1/20 | 0.30 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.30 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7018517 | 0.91 | PDE4D (0.72) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL7021594 | 0.85 | PDE4D (0.59) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL7019218 | 0.82 | PDE4B (0.49) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL7016598 | 0.80 | PDE4A (0.67) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL7020167 | 0.79 | PDE4A (0.49) | PDE4APDE4BPDE4CPDE4DSLC22A12 | |
| SCHEMBL7021808 | 0.78 | PDE4A (0.48) | PDE4APDE4BPDE4CPDE4DKDM4E | |
| SCHEMBL7019362 | 0.78 | PDE4A (0.48) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL7014555 | 0.78 | PDE4A (0.75) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL7020449 | 0.77 | PDE4A (0.76) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL7020796 | 0.76 | PDE4B (0.50) | PDE4APDE4BPDE4CPDE4D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1086106-B1 | FUROPYRIDINE DERIVATIVES AND THEIR THERAPEUTICAL USE | DARWIN DISCOVERY LTD (GB) | 2003-08-20 | — | — | EP | claimed |