Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 4/20 | 0.51 |
| ▸ | TP53 | P04637 | 3/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | NOTUM | Q6P988 | 9/20 | 0.48 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.41 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.39 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.38 |
| ▸ | BRD4 | O60885 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | CASP1 | P29466 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | CASP7 | P55210 | 1/20 | 0.38 |
| ▸ | HBB | P68871 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6968818 | 0.80 | AVPR2 (0.52) | GAATP53SMN1; SMN2MAPTPOLB | |
| SCHEMBL6959468 | 0.77 | AVPR2 (0.42) | GAATP53SMN1; SMN2MAPTPOLB | |
| SCHEMBL25629357 | 0.77 | GAA (0.54) | GAATP53SMN1; SMN2MAPTPOLB | |
| SCHEMBL14970381 | 0.76 | NOTUM (0.58) | GAATP53SMN1; SMN2NOTUMCYP11B2 | |
| SCHEMBL30158322 | 0.76 | NOTUM (0.58) | GAATP53SMN1; SMN2NOTUMCYP11B2 | |
| SCHEMBL24342186 | 0.75 | GAA (0.47) | GAATP53SMN1; SMN2MAPTPOLB | |
| SCHEMBL15632473 | 0.75 | NOTUM (0.53) | TP53NOTUMCYP11B2CYP11B1ALDH1A1 | |
| SCHEMBL7022861 | 0.73 | PDE4A (0.47) | GAATP53SMN1; SMN2MAPTPOLB | |
| SCHEMBL7012208 | 0.72 | PDE4A (0.47) | GAATP53SMN1; SMN2MAPTPOLB | |
| SCHEMBL15632547 | 0.72 | NOTUM (0.56) | POLBNOTUMCYP11B2CYP11B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1051415-B1 | BENZAMIDE DERIVATIVES AS VASOPRESSIN ANTAGONISTS | FUJISAWA PHARMACEUTICAL CO (JP) | 2003-09-24 | — | — | EP | disclosed |
| US-6495542-B1 | SUCH AS 2-METHOXY-N-(2-METHYL-1H-BENZIMIDAZOL-4-YL)-4-(2,3,4,5-TETRAHYDRO-5-OXO-1H-1-BENZAZEPIN-1-YL)CARBONYL-BENZAM IDE; HYPERTENSION, HEART FAILURE, RENAL INSUFFICIENCY, EDEMA, ASCITES, VASOPRESSIN PARASECRETION SYNDROME | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2002-12-17 | — | — | US | disclosed |
| EP-1051415-A1 | BENZAMIDE DERIVATIVES AS VASOPRESSIN ANTAGONISTS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2000-11-15 | — | — | EP | disclosed |
| WO-1999037637-A1 | BENZAMIDE DERIVATIVES AS VASOPRESSIN ANTAGONISTS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1999-07-29 | — | — | WO | disclosed |