Sugi Predict

Sugi Predict / Compounds / SCHEMBL24342186

SCHEMBL24342186

SCHEMBL24342186

CN1CCN(C)c2ncccc21

nearest known ligand 0.47

Predicted protein targets (top 8)

geneUniProtsupporting neighboursconfidence
▸ GAA P10253 4/20 0.47
▸ TP53 P04637 3/20 0.47
▸ SMN1; SMN2 Q16637 2/20 0.46
▸ MAPT P10636 1/20 0.44
▸ POLB P06746 1/20 0.44
▸ LMNA P02545 1/20 0.41
▸ DRD2 P14416 1/20 0.39
▸ EPHX2 P34913 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL178982 0.85 GAA (0.45) GAATP53SMN1; SMN2MAPTPOLB
SCHEMBL22313607 0.84 GAA (0.43) GAATP53SMN1; SMN2MAPTPOLB
SCHEMBL25629019 0.81 GAA (0.41) GAATP53SMN1; SMN2MAPTPOLB
SCHEMBL23344744 0.81 GAA (0.41) GAATP53SMN1; SMN2MAPTPOLB
SCHEMBL24278468 0.81 GAA (0.38) GAATP53SMN1; SMN2MAPTPOLB
SCHEMBL12405333 0.76 MEN1 (0.38) POLBEPHX2
SCHEMBL517896 0.76 HTR2A (0.42) EPHX2
SCHEMBL25629357 0.75 GAA (0.54) GAATP53SMN1; SMN2MAPTPOLB
SCHEMBL7020652 0.75 GAA (0.51) GAATP53SMN1; SMN2MAPTPOLB
SCHEMBL256377 0.75 MTNR1A (0.50) SMN1; SMN2LMNADRD2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-11912708-B2 Macrocyclic heterocycles and uses thereof KUMQUAT BIOSCIENCES INC. (US) 2024-02-27 — — US disclosed
US-11912708-B2 Macrocyclic heterocycles and uses thereof KUMQUAT BIOSCIENCES INC. (US) 2024-02-27 — — US disclosed
US-20230365605-A1 BICYCLIC HETEROARYL COMPOUNDS AND USES THEREOF WILMINGTON TRUST, NATIONAL ASSOCIATION, AS AGENT 2023-11-16 — — US disclosed
US-20230365605-A1 BICYCLIC HETEROARYL COMPOUNDS AND USES THEREOF WILMINGTON TRUST, NATIONAL ASSOCIATION, AS AGENT 2023-11-16 — — US disclosed
WO-2023205701-A1 MACROCYCLIC HETEROCYCLES AND USES THEREOF KUMQUAT BIOSCIENCES INC. (US) 2023-10-26 — — WO disclosed
US-20230339952-A1 MACROCYCLIC HETEROCYCLES AND USES THEREOF KUMQUAT BIOSCIENCES INC. 2023-10-26 — — US disclosed
WO-2022146698-A1 SOS1 INHIBITORS AND USES THEREOF Revolution Medicines, Inc. (US) 2022-07-07 — — WO disclosed
WO-2022081912-A2 HETEROCYCLES AND USES THEREOF KUMQUAT BIOSCIENCES INC. (US) 2022-04-21 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11912708-B2 Macrocyclic heterocycles and uses thereof HRAS, KRAS, TP53 GAA 4116/4885TP53 3/4885SMN1; SMN2 1539/4885
US-20230365605-A1 BICYCLIC HETEROARYL COMPOUNDS AND USES THEREOF SOST, SOS1, SOS2 GAA 990/4885TP53 2038/4885SMN1; SMN2 432/4885
US-20230339952-A1 MACROCYCLIC HETEROCYCLES AND USES THEREOF HRAS, KRAS, TP53 GAA 4116/4885TP53 3/4885SMN1; SMN2 1539/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.