Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AGTR1 | P30556 | 10/20 | 0.43 |
| ▸ | AGTR2 | P50052 | 3/20 | 0.42 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.41 |
| ▸ | GP6 | Q9HCN6 | 1/20 | 0.41 |
| ▸ | LTB4R2 | Q9NPC1 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7021774 | 0.93 | AGTR1 (0.41) | AGTR1AGTR2ABCB11GP6LTB4R2 | |
| SCHEMBL7012452 | 0.93 | PTPN1 (0.42) | AGTR1AGTR2ABCB11GP6LTB4R2 | |
| SCHEMBL7020457 | 0.92 | AGTR1 (0.40) | AGTR1AGTR2ABCB11GP6LTB4R2 | |
| SCHEMBL7020468 | 0.92 | AGTR1 (0.40) | AGTR1AGTR2ABCB11GP6LTB4R2 | |
| SCHEMBL7015549 | 0.90 | AGTR1 (0.47) | AGTR1AGTR2ABCB11GP6LTB4R2 | |
| SCHEMBL7017110 | 0.89 | AGTR1 (0.48) | AGTR1AGTR2ABCB11GP6LTB4R2 | |
| SCHEMBL7015176 | 0.87 | AGTR1 (0.49) | AGTR1AGTR2ABCB11GP6LTB4R2 | |
| SCHEMBL9278666 | 0.80 | CYP19A1 (0.42) | AGTR1 | |
| SCHEMBL7015525 | 0.80 | AGTR1 (0.41) | AGTR1AGTR2ABCB11GP6LTB4R2 | |
| SCHEMBL7016171 | 0.79 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0574174-B1 | Angiotensin II antagonists | LILLY CO ELI (US) | 2003-08-13 | — | — | EP | disclosed |
| US-5612360-A | AROMATIC N-HETEROCYCLIC COMPOUNDS AS HYPOTENSIVE AGENTS WITH ACID GROUPS, SULFONYLCARBOXAMIDES OR TETRAZOLE GROUPS | ELI LILLY AND COMPANY (US) | 1997-03-18 | — | — | US | disclosed |
| US-5569768-A | USEFUL IN TREATING HYPERTENSION, CONGESTIVE HEART FAILURE, GLAUCOMA AND RENAL INSUFFICIENCY | ELI LILLY AND COMPANY (US) | 1996-10-29 | — | — | US | disclosed |
| US-5556981-A | Angiotensin II antagonist intermediates | ELI LILLY AND COMPANY (US) | 1996-09-17 | — | — | US | disclosed |
| EP-0574174-A2 | Angiotensin II antagonists | ELI LILLY AND COMPANY (US) | 1993-12-15 | — | — | EP | disclosed |