Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Lithium Ion. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR3A | P46098 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4324126 | 0.92 | HTR3A (0.46) | HTR3AGAASMN1; SMN2CHRNA7MEN1 | |
| SCHEMBL701109 | 0.92 | HTR3A (0.46) | HTR3AGAASMN1; SMN2CHRNA7MEN1 | |
| Lithium Ion SCHEMBL701115 | 0.91 | HTR3A (0.43) | HTR3AGAACHRNA7USP30 | |
| Lithium Ion SCHEMBL702639 | 0.91 | HTR3A (0.43) | HTR3AGAACHRNA7USP30 | |
| SCHEMBL702083 | 0.91 | HTR3A (0.45) | HTR3AGAASMN1; SMN2CHRNA7MEN1 | |
| SCHEMBL702524 | 0.89 | HTR3A (0.43) | HTR3AGAASMN1; SMN2 | |
| SCHEMBL702525 | 0.89 | HTR3A (0.43) | HTR3AGAASMN1; SMN2 | |
| Lithium Ion SCHEMBL702370 | 0.88 | HTR3A (0.42) | HTR3AGAA | |
| Lithium Ion SCHEMBL699991 | 0.88 | HTR3A (0.42) | HTR3AGAA | |
| Lithium Ion SCHEMBL701408 | 0.86 | HTR3A (0.36) | HTR3AGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8124600-B2 | 5-HT3 receptor modulators, methods of making, and use thereof | ALBANY MOLECULAR RESEARCH, INC. (US) | 2012-02-28 | — | — | US | disclosed |