⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7022945 | 0.86 | EDNRA (0.34) | — | |
| SCHEMBL7954079 | 0.82 | KMT2A (0.32) | — | |
| SCHEMBL7021123 | 0.81 | CYP1A2 (0.31) | — | |
| SCHEMBL7021119 | 0.77 | KMT2A (0.33) | — | |
| SCHEMBL7023300 | 0.76 | EDNRA (0.36) | — | |
| SCHEMBL7016213 | 0.74 | EDNRB (0.33) | — | |
| SCHEMBL7022955 | 0.71 | EDNRA (0.34) | — | |
| SCHEMBL7952656 | 0.70 | EDNRA (0.35) | — | |
| SCHEMBL7019009 | 0.69 | EDNRA (0.44) | — | |
| SCHEMBL7022948 | 0.66 | EDNRA (0.35) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0898571-B1 | THIENO-PYRIDINE SULFONAMIDES, DERIVATIVES THEREOF AND RELATED COMPOUNDS THAT MODULATE THE ACTIVITY OF ENDOTHELIN | ENCYSIVE PHARMACEUTICALS INC (US) | 2003-11-19 | — | — | EP | disclosed |
| US-6545014-B2 | Glaucoma; adjusting concentration of nitric oxide; hypotensive, antispasmodic, antiischemic, cardiotonic agents; bronchodilators; urogentital disorders; agonists, antagonists for endothelin receptors | TEXAS BIOTECHNOLOGY CORPORATION | 2003-04-08 | — | — | US | disclosed |
| US-20020028829-A1 | Thieno-pyridine sulfonamides derivatives thereof and related compounds that modulate the activity of endothelin | ENCYSIVE PHARMACEUTICALS INC. | 2002-03-07 | — | — | US | disclosed |
| US-6329387-B2 | ANTIHISTAMINE, ANTIINFLAMMATORY AGENTS, VISION DEFECTS | TEXAS BIOTECHNOLOGY CORPORATION. | 2001-12-11 | — | — | US | disclosed |
| US-20010014684-A1 | THIENO-PYRIDINE SULFONAMIDES DERIVATIVES THEREOF AND RELATED COMPOUNDS THAT MODULATE THE ACTIVITY OF ENDOTHELIN | ENCYSIVE PHARMACEUTICALS INC. | 2001-08-16 | — | — | US | disclosed |
| US-6013655-A | HYPOTENSIVE AGENTS; RESPIRATORY SYSTEM DIISORDERS | TEXAS BIOTECHNOLOGY CORPORATION (US) | 2000-01-11 | — | — | US | disclosed |