Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.30 |
| ▸ | GAA | P10253 | 1/20 | 0.30 |
| ▸ | EDNRA | P25101 | 1/20 | 0.30 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
| ▸ | HPGD | P15428 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7952656 | 0.86 | EDNRA (0.35) | KMT2ANPSR1CYP1A2POLBCYP2C9 | |
| SCHEMBL7021113 | 0.82 | — | — | |
| SCHEMBL7021119 | 0.81 | KMT2A (0.33) | KMT2ANPSR1CYP1A2POLBCYP2C9 | |
| SCHEMBL7021123 | 0.77 | CYP1A2 (0.31) | KMT2ANPSR1CYP1A2POLBCYP2C9 | |
| SCHEMBL7022948 | 0.71 | EDNRA (0.35) | KMT2ANPSR1CYP1A2POLBCYP2C9 | |
| SCHEMBL7022945 | 0.70 | EDNRA (0.34) | EDNRA | |
| SCHEMBL7019009 | 0.68 | EDNRA (0.44) | EDNRAHPGD | |
| SCHEMBL7022955 | 0.67 | EDNRA (0.34) | GAAEDNRA | |
| SCHEMBL8325380 | 0.65 | KDM4E (0.34) | KMT2ANPSR1CYP1A2POLBCYP2C9 | |
| SCHEMBL24823033 | 0.64 | NFE2L2 (0.35) | POLBEDNRA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6329387-B2 | ANTIHISTAMINE, ANTIINFLAMMATORY AGENTS, VISION DEFECTS | TEXAS BIOTECHNOLOGY CORPORATION. | 2001-12-11 | — | — | US | disclosed |
| EP-0898571-A1 | THIENO-PYRIDINE SULFONAMIDES, DERIVATIVES THEREOF AND RELATED COMPOUNDS THAT MODULATE THE ACTIVITY OF ENDOTHELIN | TEXAS BIOTECHNOLOGY CORPORATION (US) | 1999-03-03 | — | — | EP | disclosed |
| WO-1997039000-A1 | THIENO-PYRIDINE SULFONAMIDES, DERIVATIVES THEREOF AND RELATED COMPOUNDS THAT MODULATE THE ACTIVITY OF ENDOTHELIN | TEXAS BIOTECHNOLOGY CORPORATION (US) | 1997-10-23 | — | — | WO | disclosed |