Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RORC | P51449 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.38 |
| ▸ | MEN1 | O00255 | 4/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | IDO1 | P14902 | 2/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | TDO2 | P48775 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 4/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | KDR | P35968 | 1/20 | 0.35 |
| ▸ | MST1R | Q04912 | 1/20 | 0.35 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.34 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.34 |
| ▸ | PTPN6 | P29350 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | NAMPT | P43490 | 1/20 | 0.34 |
| ▸ | CA12 | O43570 | 1/20 | 0.34 |
| ▸ | CA1 | P00915 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7022387 | 1.00 | RORC (0.40) | RORCKMT2AMEN1KDM4EPOLB | |
| SCHEMBL6318824 | 0.92 | KMT2A (0.45) | KMT2AMEN1KDM4EPOLBSMN1; SMN2 | |
| SCHEMBL6320845 | 0.92 | KMT2A (0.45) | KMT2AMEN1KDM4EPOLBSMN1; SMN2 | |
| SCHEMBL6320327 | 0.92 | IDO1 (0.39) | RORCKMT2AMEN1KDM4EPOLB | |
| SCHEMBL6320337 | 0.92 | IDO1 (0.39) | RORCKMT2AMEN1KDM4EPOLB | |
| SCHEMBL6321837 | 0.90 | IDO1 (0.38) | RORCKMT2AMEN1KDM4EPOLB | |
| SCHEMBL6321829 | 0.90 | IDO1 (0.38) | RORCKMT2AMEN1KDM4EPOLB | |
| SCHEMBL7020980 | 0.89 | IDO1 (0.40) | RORCKMT2AMEN1KDM4EPOLB | |
| SCHEMBL7020984 | 0.89 | IDO1 (0.40) | RORCKMT2AMEN1KDM4EPOLB | |
| SCHEMBL6326944 | 0.88 | MEN1 (0.38) | RORCKMT2AMEN1KDM4EPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1115704-B1 | NOVEL SUBSTITUTED INDOLINONES WITH AN INHIBITORY EFFECT ON VARIOUS KINASES AND CYCLIN/CDK COMPLEXES | BOEHRINGER INGELHEIM PHARMA (DE) | 2003-06-18 | — | — | EP | disclosed |