Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ZAP70 | P43403 | 1/20 | 0.39 |
| ▸ | SYK | P43405 | 1/20 | 0.39 |
| ▸ | GSK3B | P49841 | 2/20 | 0.39 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.39 |
| ▸ | CDK1 | P06493 | 1/20 | 0.39 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.39 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.39 |
| ▸ | CDK2 | P24941 | 1/20 | 0.39 |
| ▸ | GSK3A | P49840 | 1/20 | 0.39 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.39 |
| ▸ | TAOK1 | Q7L7X3 | 1/20 | 0.39 |
| ▸ | CCNB3 | Q8WWL7 | 1/20 | 0.39 |
| ▸ | SLK | Q9H2G2 | 1/20 | 0.39 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.39 |
| ▸ | CSNK1G1 | Q9HCP0 | 1/20 | 0.39 |
| ▸ | MERTK | Q12866 | 1/20 | 0.38 |
| ▸ | DPP7 | Q9UHL4 | 2/20 | 0.37 |
| ▸ | DPP4 | P27487 | 7/20 | 0.37 |
| ▸ | KDM1A | O60341 | 1/20 | 0.37 |
| ▸ | TPH1 | P17752 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5091305 | 0.87 | ALDH1A1 (0.41) | ZAP70SYKGSK3BCCNB2CDK1 | |
| SCHEMBL27541489 | 0.86 | GSK3B (0.39) | GSK3BCCNB2CDK1CCNB1RPS6KB1 | |
| SCHEMBL5092032 | 0.85 | GSK3B (0.44) | GSK3BDPP7DPP4 | |
| SCHEMBL27559821 | 0.83 | MERTK (0.43) | ZAP70SYKGSK3BGSK3AMERTK | |
| SCHEMBL27559810 | 0.82 | GSK3B (0.46) | ZAP70SYKGSK3BCCNB2CDK1 | |
| SCHEMBL7021332 | 0.80 | EIF4E (0.38) | ZAP70SYKGSK3BCCNB2CDK1 | |
| SCHEMBL5093431 | 0.79 | ALDH1A1 (0.45) | GSK3BCCNB2CDK1CCNB1RPS6KB1 | |
| SCHEMBL5092422 | 0.78 | GSK3B (0.45) | GSK3BCCNB2CDK1CCNB1RPS6KB1 | |
| SCHEMBL5099247 | 0.78 | MAPK8 (0.44) | ZAP70SYKGSK3BDPP7DPP4 | |
| SCHEMBL27559808 | 0.78 | EIF4E (0.39) | ZAP70SYKGSK3BCCNB2CDK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1317433-A2 | INHIBITORS OF GLYCOGEN SYNTHASE KINASE 3 | CHIRON CORPORATION (US) | 2003-06-11 | — | — | EP | disclosed |
| WO-2002020495-A2 | INHIBITORS OF GLYCOGEN SYNTHASE KINASE 3 | CHIRON CORPORATION (US) | 2002-03-14 | — | — | WO | disclosed |