Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.42 |
| ▸ | EGFR | P00533 | 3/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 3/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | ACACA | Q13085 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | ATM | Q13315 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | USP2 | O75604 | 1/20 | 0.38 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.38 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28834516 | 0.81 | KDM4E (0.39) | CYP1A2CYP2C19KDM4EL3MBTL1TDP1 | |
| SCHEMBL10370767 | 0.81 | KDM4E (0.41) | CYP1A2CYP2C19KDM4EL3MBTL1TDP1 | |
| SCHEMBL1650809 | 0.80 | KDM4E (0.50) | KDM4ETDP1HPGDALDH1A1HSD17B10 | |
| SCHEMBL1260300 | 0.78 | KDM4E (0.39) | CYP1A2CYP2C19KDM4EL3MBTL1TDP1 | |
| SCHEMBL11116972 | 0.78 | KDM4E (0.39) | CYP1A2CYP2C19KDM4EL3MBTL1TDP1 | |
| SCHEMBL3147406 | 0.78 | KDM4E (0.39) | SMN1; SMN2CYP2C19KDM4ETDP1HPGD | |
| SCHEMBL27610645 | 0.78 | ACP3 (0.34) | SMN1; SMN2CYP1A2KDM4EL3MBTL1TDP1 | |
| SCHEMBL7135689 | 0.76 | KDM4E (0.42) | SMN1; SMN2CYP1A2CYP2C19KDM4EL3MBTL1 | |
| SCHEMBL7279171 | 0.76 | KMT2A (0.45) | SMN1; SMN2KDM4EMAPTHPGDALDH1A1 | |
| SCHEMBL2090282 | 0.74 | MAPT (0.33) | SMN1; SMN2KDM4ETDP1MAPTHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2002038557-A9 | BENZOYLBENZOFURANE DERIVATIVES FOR TREATMENT OF CARDIAC ARRHYTHMIA | ARYX THERAPEUTICS (US) | 2003-09-18 | — | — | WO | disclosed |
| EP-1322630-A2 | BENZOYLBENZOFURANE DERIVATIVES FOR TREATMENT OF CARDIAC ARRHYTHMIA | Aryx Therapeutics (US) | 2003-07-02 | — | — | EP | disclosed |
| WO-2002038557-A2 | BENZOYLBENZOFURANE DERIVATIVES FOR TREATMENT OF CARDIAC ARRHYTHMIA | ARYX THERAPEUTICS (US) | 2002-05-16 | — | — | WO | disclosed |
| US-6316487-B1 | FOR THERAPY OF VENTRICULAR TACHYARRHYTHMIAS, ESPECIALLY IN PATIENTS WITH CONGESTIVE HEART FAILURE AND VENTRICULAR ARRHYTHMIAS AND SUPRAVENTRICULAR ARRHYTHMIAS, INCLUDING ATRIAL FIBRILLATION AND RE-ENTRANT TACHYARRHYTHMIAS | ARYX THERAPEUTICS | 2001-11-13 | — | — | US | disclosed |
| US-6130240-A | Compound for treatment of cardiac arrhythmia, synthesis, and methods of use | ARYX THERAPEUTICS, INC. (US) | 2000-10-10 | — | — | US | disclosed |
| US-5849788-A | Compound for treatment of cardiac arphythmia, synthesis, and methods of use | ARYX THERAPEUTICS (US) | 1998-12-15 | — | — | US | disclosed |
| EP-0703910-B1 | BENZOYLBENZOFURANE DERIVATIVES FOR TREATMENT OF CARDIAC ARRHYTHMIA | ARYX THERAPEUTICS (US) | 1998-01-07 | — | — | EP | disclosed |
| EP-0703910-A1 | BENZOYLBENZOFURANE DERIVATIVES FOR TREATMENT OF CARDIAC ARRHYTHMIA | Advanced Therapies, Inc. (US) | 1996-04-03 | — | — | EP | disclosed |
| US-5440054-A | Compound for treatment of cardiac arrhythmia, synthesis, and methods of use | ADVANCED THERAPIES, INC. (US) | 1995-08-08 | — | — | US | disclosed |
| WO-1994029289-A1 | BENZOYLBENZOFURANE DERIVATIVES FOR TREATMENT OF CARDIAC ARRHYTHMIA | ADVANCED THERAPIES, INC. (US) | 1994-12-22 | — | — | WO | disclosed |
| US-5364880-A | Compound for treatment of cardiac arrhythmia, synthesis, and methods of use | ADVANCED THERAPIES, INC. (US) | 1994-11-15 | — | — | US | disclosed |