Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.37 |
| ▸ | HPGD | P15428 | 6/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.34 |
| ▸ | GLA | P06280 | 2/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 4/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.32 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.32 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.32 |
| ▸ | NR4A3 | Q92570 | 1/20 | 0.32 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.32 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10370767 | 0.85 | KDM4E (0.41) | KDM4ETDP1HPGDALDH1A1GLA | |
| SCHEMBL1650809 | 0.84 | KDM4E (0.50) | KDM4ETDP1HPGDALDH1A1GLA | |
| SCHEMBL3147406 | 0.82 | KDM4E (0.39) | KDM4ETDP1HPGDALDH1A1GLA | |
| SCHEMBL1260300 | 0.82 | KDM4E (0.39) | KDM4ETDP1HPGDALDH1A1GLA | |
| SCHEMBL28834516 | 0.82 | KDM4E (0.39) | KDM4ETDP1HPGDALDH1A1GLA | |
| SCHEMBL7022984 | 0.78 | SMN1; SMN2 (0.46) | KDM4ETDP1HPGDALDH1A1HSD17B10 | |
| SCHEMBL27610645 | 0.78 | ACP3 (0.34) | KDM4ETDP1HPGDALDH1A1HSD17B10 | |
| SCHEMBL9935525 | 0.75 | TDP1 (0.35) | KDM4ETDP1ALDH1A1HSD17B10GAA | |
| SCHEMBL1746782 | 0.75 | MAOB (0.40) | KDM4ETDP1HPGDALDH1A1HSD17B10 | |
| SCHEMBL1259581 | 0.75 | KDM4E (0.36) | KDM4ETDP1HPGDALDH1A1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4460594-A | CENTRAL NERVOUS SYSTEM DISORDERS | BEECHAM GROUP P.L.C. (GB) | 1984-07-17 | — | — | US | disclosed |
| EP-0077607-A1 | N-substituted 3-aryl piperidines and derivatives thereof | BEECHAM GROUP PLC (GB) | 1983-04-27 | — | — | EP | disclosed |