SCHEMBL7023441

SCHEMBL7023441

CCc1c(O)ccc(OP(=O)(O)O)c1CC

nearest known ligand 0.47

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
INPPL1 O15357 11/20 0.47
INPP5A Q14642 6/20 0.47
AKT1 P31749 1/20 0.47
INPP5B P32019 2/20 0.42
BLM P54132 1/20 0.39
SRC P12931 2/20 0.36
KDM4E B2RXH2 1/20 0.36
USP2 O75604 1/20 0.36
ALDH1A1 P00352 1/20 0.36
HPGD P15428 1/20 0.36
PDE3A Q14432 1/20 0.36
HSD17B10 Q99714 1/20 0.36
CYP2C19 P33261 1/20 0.35
SMN1; SMN2 Q16637 1/20 0.35
POLB P06746 1/20 0.35
THRA P10827 1/20 0.33
THRB P10828 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7023436 0.87 POLB (0.36) INPPL1INPP5AAKT1BLMKDM4E
SCHEMBL382005 0.84 INPPL1 (0.48) INPPL1INPP5AAKT1INPP5BBLM
SCHEMBL29493898 0.84 INPPL1 (0.48) INPPL1INPP5AAKT1INPP5BBLM
SCHEMBL6036493 0.78 SRC (0.51) INPPL1INPP5AAKT1INPP5BBLM
SCHEMBL29065640 0.78 ALOX5 (0.42) INPPL1INPP5AAKT1
SCHEMBL1727473 0.77 INPPL1 (0.46) INPPL1INPP5AAKT1INPP5BBLM
SCHEMBL2526898 0.76 CA1 (0.41) INPPL1INPP5AAKT1INPP5BBLM
SCHEMBL2526896 0.76 CA1 (0.41) INPPL1INPP5AAKT1INPP5BBLM
SCHEMBL761162 0.75 INPPL1 (0.53) INPPL1INPP5AAKT1INPP5BBLM
SCHEMBL25328734 0.75 MAOB (0.43) BLMKDM4EALDH1A1HPGDHSD17B10

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0574174-B1 Angiotensin II antagonists LILLY CO ELI (US) 2003-08-13 EP disclosed
US-5693633-A Angiotensin II antagonists ELI LILLY AND COMPANY (US) 1997-12-02 US disclosed
US-5612360-A AROMATIC N-HETEROCYCLIC COMPOUNDS AS HYPOTENSIVE AGENTS WITH ACID GROUPS, SULFONYLCARBOXAMIDES OR TETRAZOLE GROUPS ELI LILLY AND COMPANY (US) 1997-03-18 US disclosed
US-5569768-A USEFUL IN TREATING HYPERTENSION, CONGESTIVE HEART FAILURE, GLAUCOMA AND RENAL INSUFFICIENCY ELI LILLY AND COMPANY (US) 1996-10-29 US disclosed
US-5556981-A Angiotensin II antagonist intermediates ELI LILLY AND COMPANY (US) 1996-09-17 US disclosed
US-5484780-A CARDIOVASCULAR, HYPOTENSIVE ELI LILLY AND COMPANY (US) 1996-01-16 US disclosed
US-5401851-A Preparation of proline derivatives ELI LILLY AND COMPANY (US) 1995-03-28 US disclosed
EP-0574174-A2 Angiotensin II antagonists ELI LILLY AND COMPANY (US) 1993-12-15 EP disclosed
EP-0573271-A1 Angiotensin II antagonists ELI LILLY AND COMPANY (US) 1993-12-08 EP disclosed