Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LCK | P06239 | 10/20 | 0.62 |
| ▸ | AURKA | O14965 | 1/20 | 0.57 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.57 |
| ▸ | JAK2 | O60674 | 1/20 | 0.51 |
| ▸ | JAK3 | P52333 | 1/20 | 0.51 |
| ▸ | MAPK14 | Q16539 | 6/20 | 0.47 |
| ▸ | MAPK13 | O15264 | 3/20 | 0.47 |
| ▸ | MAPK12 | P53778 | 3/20 | 0.47 |
| ▸ | MAPK11 | Q15759 | 3/20 | 0.47 |
| ▸ | MKNK1 | Q9BUB5 | 2/20 | 0.45 |
| ▸ | MKNK2 | Q9HBH9 | 2/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7014868 | 0.93 | LCK (0.69) | LCKAURKAAURKBJAK2JAK3 | |
| SCHEMBL7021040 | 0.91 | LCK (0.64) | LCKAURKAAURKBJAK2JAK3 | |
| SCHEMBL7025640 | 0.90 | LCK (0.60) | LCKAURKAAURKBJAK2JAK3 | |
| SCHEMBL7028475 | 0.89 | LCK (0.59) | LCKAURKAAURKBJAK2JAK3 | |
| SCHEMBL7024433 | 0.88 | LCK (0.62) | LCKAURKAAURKBJAK2JAK3 | |
| SCHEMBL7018072 | 0.86 | LCK (0.62) | LCKAURKAAURKBJAK2JAK3 | |
| SCHEMBL7105532 | 0.84 | LCK (0.60) | LCKAURKAAURKBJAK2JAK3 | |
| SCHEMBL7100716 | 0.84 | LCK (0.63) | LCKAURKAAURKBJAK2JAK3 | |
| SCHEMBL7100712 | 0.84 | LCK (0.63) | LCKAURKAAURKBJAK2JAK3 | |
| SCHEMBL7105538 | 0.84 | LCK (0.60) | LCKAURKAAURKBJAK2JAK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1206265-B1 | SRC KINASE INHIBITOR COMPOUNDS | MERCK & CO INC (US) | 2003-11-12 | — | — | EP | disclosed |
| US-6498165-B1 | PYRIMIDINE COMPOUNDS; PROPHYLAXIS AND TREATMENT OF SUCH AS IMMUNE DISEASES, HYPERPROLIFERATIVE DISORDERS, CANCER, ANGIOGENSIS, ATHEROSCELEROSIS, GRAFT REJECTION, RHEUMATOID ARTHRITIS, PSORIASIS | MERCK & CO., INC. | 2002-12-24 | — | — | US | disclosed |