Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LCK | P06239 | 12/20 | 0.62 |
| ▸ | JAK2 | O60674 | 4/20 | 0.51 |
| ▸ | JAK3 | P52333 | 4/20 | 0.51 |
| ▸ | ATP1A1 | P05023 | 1/20 | 0.47 |
| ▸ | ATP1B1 | P05026 | 1/20 | 0.47 |
| ▸ | ATP1A3 | P13637 | 1/20 | 0.47 |
| ▸ | ATP1B2 | P14415 | 1/20 | 0.47 |
| ▸ | ATP1A2 | P50993 | 1/20 | 0.47 |
| ▸ | ATP1B3 | P54709 | 1/20 | 0.47 |
| ▸ | FXYD2 | P54710 | 1/20 | 0.47 |
| ▸ | ATP1A4 | Q13733 | 1/20 | 0.47 |
| ▸ | AURKA | O14965 | 1/20 | 0.46 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.46 |
| ▸ | MKNK1 | Q9BUB5 | 2/20 | 0.45 |
| ▸ | MKNK2 | Q9HBH9 | 2/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7014868 | 0.91 | LCK (0.69) | LCKJAK2JAK3AURKAAURKB | |
| SCHEMBL7021040 | 0.89 | LCK (0.64) | LCKJAK2JAK3AURKAAURKB | |
| SCHEMBL7023496 | 0.88 | LCK (0.62) | LCKJAK2JAK3AURKAAURKB | |
| SCHEMBL7021158 | 0.87 | LCK (0.58) | LCKJAK2JAK3AURKAAURKB | |
| SCHEMBL7025640 | 0.86 | LCK (0.60) | LCKJAK2JAK3AURKAAURKB | |
| SCHEMBL7028475 | 0.85 | LCK (0.59) | LCKJAK2JAK3ATP1A1ATP1B1 | |
| SCHEMBL7105532 | 0.84 | LCK (0.60) | LCKJAK2JAK3AURKAAURKB | |
| SCHEMBL7100716 | 0.84 | LCK (0.63) | LCKJAK2JAK3AURKAAURKB | |
| SCHEMBL7100712 | 0.84 | LCK (0.63) | LCKJAK2JAK3AURKAAURKB | |
| SCHEMBL7105538 | 0.84 | LCK (0.60) | LCKJAK2JAK3AURKAAURKB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1206265-B1 | SRC KINASE INHIBITOR COMPOUNDS | MERCK & CO INC (US) | 2003-11-12 | — | — | EP | disclosed |
| US-6498165-B1 | PYRIMIDINE COMPOUNDS; PROPHYLAXIS AND TREATMENT OF SUCH AS IMMUNE DISEASES, HYPERPROLIFERATIVE DISORDERS, CANCER, ANGIOGENSIS, ATHEROSCELEROSIS, GRAFT REJECTION, RHEUMATOID ARTHRITIS, PSORIASIS | MERCK & CO., INC. | 2002-12-24 | — | — | US | disclosed |