Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SRC | P12931 | 14/20 | 0.72 |
| ▸ | EGFR | P00533 | 11/20 | 0.72 |
| ▸ | ABL1 | P00519 | 9/20 | 0.72 |
| ▸ | ABL2 | P42684 | 9/20 | 0.72 |
| ▸ | LCK | P06239 | 1/20 | 0.72 |
| ▸ | HCK | P08631 | 1/20 | 0.64 |
| ▸ | BTK | Q06187 | 2/20 | 0.63 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.63 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7020164 | 0.94 | SRC (0.81) | SRCEGFRABL1ABL2LCK | |
| SCHEMBL8099110 | 0.91 | SRC (0.71) | SRCEGFRABL1ABL2LCK | |
| SCHEMBL7023786 | 0.90 | ABL1 (0.89) | SRCEGFRABL1ABL2LCK | |
| SCHEMBL7017495 | 0.90 | SRC (0.61) | SRCEGFRABL1ABL2LCK | |
| SCHEMBL8107889 | 0.89 | SRC (0.64) | SRCEGFRABL1ABL2LCK | |
| SCHEMBL8098878 | 0.88 | SRC (0.63) | SRCEGFRABL1ABL2LCK | |
| SCHEMBL7014534 | 0.85 | SRC (0.59) | SRCEGFRABL1ABL2LCK | |
| SCHEMBL8107249 | 0.84 | SRC (0.80) | SRCEGFRABL1ABL2LCK | |
| SCHEMBL8108556 | 0.84 | ABL1 (1.00) | SRCEGFRABL1ABL2LCK | |
| SCHEMBL8114235 | 0.83 | SRC (0.71) | SRCEGFRABL1ABL2LCK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0888353-B1 | N-7-HETEROCYCLYL PYRROLO [2,3-d]PYRIMIDINES AND THEIR USE | NOVARTIS AG (CH) | 2003-07-09 | — | — | EP | disclosed |
| US-6051577-A | TYROSINE INHIBITORS; BONE DISORDERS | NOVARTIS AG (CH) | 2000-04-18 | — | — | US | disclosed |