Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SRC | P12931 | 8/20 | 0.71 |
| ▸ | EGFR | P00533 | 5/20 | 0.71 |
| ▸ | ABL1 | P00519 | 4/20 | 0.71 |
| ▸ | ABL2 | P42684 | 4/20 | 0.71 |
| ▸ | RIPK2 | O43353 | 11/20 | 0.71 |
| ▸ | LCK | P06239 | 2/20 | 0.58 |
| ▸ | KDR | P35968 | 2/20 | 0.58 |
| ▸ | TEK | Q02763 | 2/20 | 0.58 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.58 |
| ▸ | MEN1 | O00255 | 1/20 | 0.58 |
| ▸ | RGS12 | O14924 | 1/20 | 0.58 |
| ▸ | NPC1 | O15118 | 1/20 | 0.58 |
| ▸ | GMNN | O75496 | 1/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.58 |
| ▸ | LMNA | P02545 | 1/20 | 0.58 |
| ▸ | TP53 | P04637 | 1/20 | 0.58 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.58 |
| ▸ | FYN | P06241 | 1/20 | 0.58 |
| ▸ | LYN | P07948 | 1/20 | 0.58 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7019643 | 0.94 | SRC (0.69) | SRCEGFRABL1ABL2RIPK2 | |
| SCHEMBL7024626 | 0.89 | SRC (0.70) | SRCEGFRABL1ABL2RIPK2 | |
| SCHEMBL7023217 | 0.89 | SRC (0.71) | SRCEGFRABL1ABL2RIPK2 | |
| SCHEMBL7019158 | 0.89 | ABL1 (0.74) | SRCEGFRABL1ABL2RIPK2 | |
| SCHEMBL7021401 | 0.88 | SRC (0.73) | SRCEGFRABL1ABL2RIPK2 | |
| SCHEMBL7014659 | 0.84 | ABL1 (0.72) | SRCEGFRABL1ABL2LCK | |
| SCHEMBL7027959 | 0.84 | SRC (0.66) | SRCEGFRABL1ABL2RIPK2 | |
| SCHEMBL7013342 | 0.83 | SRC (0.67) | SRCEGFRABL1ABL2RIPK2 | |
| SCHEMBL7023086 | 0.83 | SRC (0.76) | SRCEGFRABL1ABL2RIPK2 | |
| SCHEMBL28022043 | 0.83 | SRC (0.69) | SRCEGFRABL1LCKKDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0888353-B1 | N-7-HETEROCYCLYL PYRROLO [2,3-d]PYRIMIDINES AND THEIR USE | NOVARTIS AG (CH) | 2003-07-09 | — | — | EP | disclosed |