Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABL1 | P00519 | 18/20 | 0.72 |
| ▸ | EGFR | P00533 | 18/20 | 0.72 |
| ▸ | ABL2 | P42684 | 18/20 | 0.72 |
| ▸ | SRC | P12931 | 15/20 | 0.72 |
| ▸ | LCK | P06239 | 3/20 | 0.60 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.59 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.59 |
| ▸ | KDR | P35968 | 1/20 | 0.57 |
| ▸ | TEK | Q02763 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7019158 | 0.95 | ABL1 (0.74) | ABL1EGFRABL2SRCLCK | |
| SCHEMBL7019643 | 0.90 | SRC (0.69) | ABL1EGFRABL2SRCFGFR1 | |
| SCHEMBL7023375 | 0.90 | SRC (0.78) | ABL1EGFRABL2SRCLCK | |
| SCHEMBL7013342 | 0.88 | SRC (0.67) | ABL1EGFRABL2SRCLCK | |
| SCHEMBL7025034 | 0.84 | EGFR (0.75) | ABL1EGFRABL2SRCLCK | |
| SCHEMBL7023764 | 0.84 | SRC (0.71) | ABL1EGFRABL2SRCLCK | |
| SCHEMBL7020293 | 0.84 | ABL1 (0.87) | ABL1EGFRABL2SRCLCK | |
| SCHEMBL7023792 | 0.83 | ABL1 (1.00) | ABL1EGFRABL2SRCLCK | |
| SCHEMBL7013351 | 0.83 | ABL1 (0.72) | ABL1EGFRABL2SRCLCK | |
| SCHEMBL7027959 | 0.83 | SRC (0.66) | ABL1EGFRABL2SRCKDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0888353-B1 | N-7-HETEROCYCLYL PYRROLO [2,3-d]PYRIMIDINES AND THEIR USE | NOVARTIS AG (CH) | 2003-07-09 | — | — | EP | disclosed |