Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NLRP3 | Q96P20 | 3/20 | 0.71 |
| ▸ | ABCC9 | O60706 | 1/20 | 0.62 |
| ▸ | ABCC8 | Q09428 | 1/20 | 0.62 |
| ▸ | KCNJ11 | Q14654 | 1/20 | 0.62 |
| ▸ | DNMT3A | Q9Y6K1 | 1/20 | 0.62 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.58 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7018104 | 0.95 | NLRP3 (0.68) | NLRP3ABCC9ABCC8KCNJ11DNMT3A | |
| SCHEMBL7027188 | 0.94 | NLRP3 (0.67) | NLRP3ABCC9ABCC8KCNJ11DNMT3A | |
| SCHEMBL7026647 | 0.94 | NLRP3 (0.69) | NLRP3ABCC9ABCC8KCNJ11DNMT3A | |
| SCHEMBL7018076 | 0.94 | NLRP3 (0.71) | NLRP3ABCC9ABCC8KCNJ11DNMT3A | |
| SCHEMBL7023303 | 0.93 | NLRP3 (0.65) | NLRP3ABCC9ABCC8KCNJ11DNMT3A | |
| SCHEMBL4654433 | 0.91 | NLRP3 (0.78) | NLRP3ABCC9ABCC8KCNJ11DNMT3A | |
| SCHEMBL7019461 | 0.88 | NLRP3 (0.74) | NLRP3ABCC9ABCC8KCNJ11DNMT3A | |
| SCHEMBL3767959 | 0.87 | NLRP3 (0.73) | NLRP3ABCC9ABCC8KCNJ11DNMT3A | |
| SCHEMBL7021253 | 0.86 | NLRP3 (0.66) | NLRP3ABCC9ABCC8KCNJ11DNMT3A | |
| SCHEMBL6565933 | 0.85 | NLRP3 (0.70) | NLRP3ABCC9ABCC8KCNJ11DNMT3A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1330632-C | 2, 5-substituted benzenesulfonylureas and-thioureas, processes for their preparation, their use and pharmaceutical preparations comprising them | AVENTIS PHARMA GMBH (DE) | 2007-08-08 | — | — | CN | disclosed |
| EP-1100775-B1 | 2,5-SUBSTITUTED BENZOLSULFONYLUREAS AND THIOUREAS, METHODS FOR THE PRODUCTION THEREOF, USE THEREOF AND PHARMACEUTICAL PREPARATIONS CONTAINING THE SAME | AVENTIS PHARMA GMBH (DE) | 2003-12-17 | — | — | EP | disclosed |
| US-6410573-B1 | CARDIOVASCULAR DISEASES; POTASSIUM CHANNEL MODULATOR | AVENTIS PHARMA DEUTSCHLAND GMBH (DE) | 2002-06-25 | — | — | US | disclosed |
| CN-1314884-A | 2,5-substituted benzoluslfonylureas and thioureas, methods for production thereof, use thereof and pharamceutical preparations containing the same | AVENTIS PHARMA GMBH (DE) | 2001-09-26 | — | — | CN | disclosed |
| EP-1100775-A2 | 2,5-SUBSTITUTED BENZOLSULFONYLUREAS AND THIOUREAS, METHODS FOR THE PRODUCTION THEREOF, USE THEREOF AND PHARMACEUTICAL PREPARATIONS CONTAINING THE SAME | Hoechst Marion Roussel Deutschland GmbH (DE) | 2001-05-23 | — | — | EP | disclosed |
| WO-2000003978-A2 | 2,5-SUBSTITUTED BENZOLSULFONYLUREAS AND THIOUREAS, METHODS FOR THE PRODUCTION THEREOF, USE THEREOF AND PHARMACEUTICAL PREPARATIONS CONTAINING THE SAME | AVENTIS PHARMA DEUTSCHLAND GMBH (DE) | 2000-01-27 | — | — | WO | disclosed |