SCHEMBL7024042

SCHEMBL7024042

CCCCCC1COC(C2CCC(c3ccc(CCCO)c(F)c3)CC2)OC1

nearest known ligand 0.34

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
SPHK1 Q9NYA1 5/20 0.34
CA2 P00918 1/20 0.33
CYP3A4 P08684 2/20 0.32
CYP2C8 P10632 1/20 0.32
S1PR3 Q99500 1/20 0.32
MEN1 O00255 1/20 0.31
TP53 P04637 1/20 0.31
ALOX5 P09917 1/20 0.31
MAPT P10636 1/20 0.31
TYR P14679 1/20 0.31
ALOX15 P16050 1/20 0.31
TSHR P16473 1/20 0.31
HTT P42858 1/20 0.31
KMT2A Q03164 1/20 0.31
TDP1 Q9NUW8 1/20 0.31
CNR2 P34972 4/20 0.31
CTSK P43235 1/20 0.31
CTSC P53634 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7033650 0.97 CA2 (0.33) SPHK1CA2TYRCTSKCTSC
SCHEMBL7023946 0.95 SPHK1 (0.35) SPHK1CYP3A4CYP2C8S1PR3CTSK
SCHEMBL7032722 0.94 CA2 (0.34) SPHK1CA2MEN1MAPTKMT2A
SCHEMBL10503119 0.94 SPHK1 (0.33) SPHK1CYP3A4CYP2C8S1PR3MEN1
SCHEMBL10503112 0.94 SPHK1 (0.33) SPHK1CYP3A4CYP2C8S1PR3MEN1
SCHEMBL10501488 0.94 SPHK1 (0.36) SPHK1CYP3A4MEN1TP53ALOX5
SCHEMBL10501474 0.94 SPHK1 (0.36) SPHK1CYP3A4MEN1TP53ALOX5
SCHEMBL10502229 0.93 SPHK1 (0.37) SPHK1CYP3A4CYP2C8S1PR3MEN1
SCHEMBL10502238 0.93 SPHK1 (0.37) SPHK1CYP3A4CYP2C8S1PR3MEN1
SCHEMBL7026499 0.92 SPHK1 (0.33) SPHK1CTSKCTSC

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0754668-B1 Fluorobenzylether derivatives ROLIC AG (CH) 2003-02-05 EP disclosed
EP-0754668-A2 Fluorobenzylether derivatives Rolic AG (CH) 1997-01-22 EP disclosed