Known targets — ChEMBL curated mechanism
ACHECHKACHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNB1CHRNDCHRNECHRNGHRH2OPRM1
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | TSHR | P16473 | 1/20 | 0.30 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bromide SCHEMBL7018789 | 1.00 | — | — | |
| Bromide SCHEMBL1230473 | 1.00 | ALDH1A1 (0.30) | ALDH1A1TSHRHSD17B10 | |
| SCHEMBL379510 | 0.94 | TSHR (0.33) | ALDH1A1TSHRHSD17B10 | |
| SCHEMBL29511758 | 0.94 | — | — | |
| SCHEMBL6756409 | 0.94 | TSHR (0.33) | ALDH1A1TSHRHSD17B10 | |
| SCHEMBL30577237 | 0.94 | TSHR (0.33) | ALDH1A1TSHRHSD17B10 | |
| SCHEMBL3356662 | 0.94 | TSHR (0.33) | ALDH1A1TSHRHSD17B10 | |
| SCHEMBL7085 | 0.94 | TSHR (0.33) | ALDH1A1TSHRHSD17B10 | |
| SCHEMBL23521060 | 0.88 | ALDH1A1 (0.30) | ALDH1A1TSHRHSD17B10 | |
| SCHEMBL11504706 | 0.88 | ALDH1A1 (0.30) | ALDH1A1TSHRHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0789022-B1 | Difluoroprostacyclins, intermediates for production thereof and processes for production thereof | ASAHI GLASS CO LTD (JP) | 2003-06-18 | — | — | EP | disclosed |
| EP-0669329-B1 | Difluorprostacyclins, intermediates for production thereof and processes for production thereof | ASAHI GLASS CO LTD (JP) | 1998-05-20 | — | — | EP | disclosed |
| US-5747531-A | STABILITY; ANTICOAGULANTS, VASODILATORS | ASAHI GLASS COMPANY LTD. (JP) | 1998-05-05 | — | — | US | disclosed |
| EP-0789022-A1 | Difluoroprostacyclins, intermediates for production thereof and process for production | ASAHI GLASS COMPANY LTD. (JP) | 1997-08-13 | — | — | EP | disclosed |
| US-5616732-A | Intermediates for difluoroprostacyclins and methods for their production | ASAHI GLASS COMPANY LTD. (JP) | 1997-04-01 | — | — | US | disclosed |
| US-5538995-A | Difluoroprostacyclins | ASAHI GLASS COMPANY LTD. (JP) | 1996-07-23 | — | — | US | disclosed |
| EP-0669329-A1 | Difluorprostacyclins, intermediates for production thereof and processes for production thereof | ASAHI GLASS COMPANY LTD. (JP) | 1995-08-30 | — | — | EP | disclosed |