Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPA1 | O75762 | 15/20 | 0.58 |
| ▸ | FEN1 | P39748 | 1/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | THRB | P10828 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | CMA1 | P23946 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5957456 | 0.88 | TRPA1 (0.72) | TRPA1TP53MAPTALDH1A1 | |
| SCHEMBL5957675 | 0.86 | TRPA1 (0.79) | TRPA1TP53MAPT | |
| SCHEMBL5957285 | 0.86 | TRPA1 (0.76) | TRPA1TP53 | |
| SCHEMBL6236419 | 0.85 | TRPA1 (0.63) | TRPA1TP53MAPT | |
| SCHEMBL6238345 | 0.85 | TRPA1 (0.62) | TRPA1FEN1MAPTLMNA | |
| SCHEMBL6237698 | 0.85 | TRPA1 (0.60) | TRPA1FEN1ALDH1A1 | |
| SCHEMBL6236549 | 0.83 | TRPA1 (0.57) | TRPA1FEN1 | |
| SCHEMBL5957429 | 0.82 | TRPA1 (0.73) | TRPA1ALDH1A1 | |
| SCHEMBL6234041 | 0.80 | TRPA1 (0.59) | TRPA1FEN1MAPTLMNA | |
| SCHEMBL6235761 | 0.80 | TRPA1 (0.56) | TRPA1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1362054-A1 | BICYCLIC PYRIMIDINE MATRIX METALLOPROTEINASE INHIBITORS | Warner-Lambert Company LLC (US) | 2003-11-19 | — | — | EP | disclosed |
| WO-2002064599-A1 | BICYCLIC PYRIMIDINE MATRIX METALLOPROTEINASE INHIBITORS | WARNER-LAMBERT COMPANY LLC (US) | 2002-08-22 | — | — | WO | disclosed |