Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NISCH | Q9Y2I1 | 3/20 | 0.60 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | HTR5A | P47898 | 1/20 | 0.46 |
| ▸ | NR2E1 | Q9Y466 | 1/20 | 0.46 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.46 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.46 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.46 |
| ▸ | HTR7 | P34969 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
| ▸ | THRB | P10828 | 1/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.43 |
| ▸ | RECQL | P46063 | 1/20 | 0.43 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | TAAR1 | Q96RJ0 | 2/20 | 0.38 |
| ▸ | HTR2A | P28223 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8814257 | 0.82 | NISCH (0.52) | NISCHKDM4EHTR5ANR2E1ADRA2A | |
| SCHEMBL18457809 | 0.81 | GFER (0.45) | NISCHKDM4ELMNAALOX15HSD17B10 | |
| SCHEMBL2972622 | 0.78 | NISCH (0.68) | NISCHKDM4EHTR5ANR2E1ADRA2A | |
| Hydrochloric Acid SCHEMBL9615116 | 0.77 | NISCH (0.66) | NISCHKDM4EHTR5ANR2E1ADRA2A | |
| SCHEMBL14581529 | 0.72 | TAAR1 (0.54) | NISCHKDM4EADRA2AADRA2BADRA2C | |
| SCHEMBL11489617 | 0.72 | NISCH (0.48) | NISCHKDM4EHTR5ANR2E1ADRA2A | |
| Hydrochloric Acid SCHEMBL4792660 | 0.71 | TAAR1 (0.56) | NISCHKDM4EADRA2AADRA2BADRA2C | |
| SCHEMBL25424536 | 0.70 | NISCH (0.69) | NISCHKDM4EHTR5ANR2E1ADRA2A | |
| SCHEMBL3476607 | 0.70 | TAAR1 (0.51) | NISCHTAAR1HTR2AHTR2CPNMT | |
| SCHEMBL8801548 | 0.70 | TAAR1 (0.44) | NISCHKDM4EHTR5ANR2E1ADRA2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0705832-B1 | Serotonergic modulators | LILLY CO ELI (GB) | 2003-08-13 | — | — | EP | disclosed |
| US-5563147-A | CENTRAL NERVOUS SYSTEM DISORDERS | ELI LILLY AND COMPANY (US) | 1996-10-08 | — | — | US | disclosed |
| EP-0705832-A1 | Serotonergic modulators | LILLY INDUSTRIES LIMITED (GB) | 1996-04-10 | — | — | EP | disclosed |