Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TOP1 | P11387 | 13/20 | 0.51 |
| ▸ | CDK4 | P11802 | 4/20 | 0.38 |
| ▸ | CCND1 | P24385 | 4/20 | 0.38 |
| ▸ | SSTR1 | P30872 | 1/20 | 0.37 |
| ▸ | SSTR2 | P30874 | 1/20 | 0.37 |
| ▸ | SSTR4 | P31391 | 1/20 | 0.37 |
| ▸ | SSTR3 | P32745 | 1/20 | 0.37 |
| ▸ | SSTR5 | P35346 | 1/20 | 0.37 |
| ▸ | CCNE2 | O96020 | 3/20 | 0.35 |
| ▸ | CCNE1 | P24864 | 3/20 | 0.35 |
| ▸ | CDK2 | P24941 | 3/20 | 0.35 |
| ▸ | PRKACA | P17612 | 3/20 | 0.35 |
| ▸ | PRKACG | P22612 | 3/20 | 0.35 |
| ▸ | PRKACB | P22694 | 3/20 | 0.35 |
| ▸ | PRKCQ | Q04759 | 2/20 | 0.35 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.34 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.34 |
| ▸ | PRKCG | P05129 | 1/20 | 0.34 |
| ▸ | PRKCB | P05771 | 1/20 | 0.34 |
| ▸ | PRKCA | P17252 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5870241 | 0.94 | TOP1 (0.51) | TOP1CDK4CCND1SSTR1SSTR2 | |
| SCHEMBL5869927 | 0.93 | TOP1 (0.55) | TOP1CDK4CCND1CCNE2CCNE1 | |
| SCHEMBL7031130 | 0.88 | TOP1 (0.54) | TOP1CDK4CCND1CCNE2CCNE1 | |
| SCHEMBL5870245 | 0.87 | TOP1 (0.51) | TOP1CDK4CCND1CCNE2CCNE1 | |
| SCHEMBL7865331 | 0.86 | TOP1 (0.38) | TOP1SSTR1SSTR2SSTR4SSTR3 | |
| SCHEMBL7865328 | 0.86 | TOP1 (0.38) | TOP1SSTR1SSTR2SSTR4SSTR3 | |
| SCHEMBL5870514 | 0.86 | TOP1 (0.61) | TOP1PRKCA | |
| SCHEMBL6724824 | 0.86 | TOP1 (0.61) | TOP1PRKCA | |
| SCHEMBL6736290 | 0.86 | TOP1 (0.57) | TOP1CDK4CCND1CCNE2CCNE1 | |
| SCHEMBL7027394 | 0.85 | TOP1 (0.45) | TOP1CDK4CCND1CCNE2CCNE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20030083271-A1 | Topoisomerase I selective cytotoxic sugar derivatives of indolopyrrolocarbazoles | BRISTOL-MYERS SQUIBB COMPANY | 2003-05-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030083271-A1 | Topoisomerase I selective cytotoxic sugar derivatives of indolopyrrolocarbazoles | TOP1, TOP2A, TOP2B | TOP1 1/4885CDK4 169/4885CCND1 444/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.