SCHEMBL7025263

SCHEMBL7025263

CC1=CC(=O)C(C(C)(C)CC(=O)Oc2ccc(N(CCCl)CCCl)cc2)=C(C)C1=O

nearest known ligand 0.34

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
EGFR P00533 4/20 0.34
ERBB2 P04626 4/20 0.34
ALDH1A1 P00352 3/20 0.32
SMN1; SMN2 Q16637 3/20 0.32
HIF1A Q16665 3/20 0.32
LMNA P02545 3/20 0.32
MAPT P10636 2/20 0.32
NFKB1 P19838 2/20 0.32
THPO P40225 2/20 0.32
PMP22 Q01453 2/20 0.32
GMNN O75496 1/20 0.32
CYP2D6 P10635 1/20 0.32
GABRA1 P14867 1/20 0.32
TSHR P16473 1/20 0.32
GABRA2 P47869 1/20 0.32
GABRB2 P47870 1/20 0.32
SLCO1B3 Q9NPD5 1/20 0.32
CYP3A4 P08684 3/20 0.31
ALOX15 P16050 2/20 0.31
ABCB11 O95342 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7030587 0.92 EGFR (0.34) EGFRERBB2ALDH1A1SMN1; SMN2HIF1A
SCHEMBL7030683 0.87 EGFR (0.35) EGFRERBB2ALDH1A1SMN1; SMN2HIF1A
SCHEMBL7020871 0.87 EGFR (0.36) EGFRERBB2ALDH1A1SMN1; SMN2HIF1A
SCHEMBL7029176 0.85 PTPN1 (0.34) EGFRERBB2ALDH1A1SMN1; SMN2HIF1A
SCHEMBL7027358 0.83 EGFR (0.35) EGFRERBB2ALDH1A1SMN1; SMN2HIF1A
SCHEMBL7026779 0.82 HDAC6 (0.33) EGFRERBB2ALDH1A1SMN1; SMN2HIF1A
SCHEMBL7023727 0.81 EGFR (0.37) EGFRERBB2ALDH1A1SMN1; SMN2HIF1A
SCHEMBL7024485 0.81 EGFR (0.34) EGFRERBB2ALDH1A1SMN1; SMN2HIF1A
SCHEMBL7024459 0.79 CA12 (0.33) EGFRERBB2ALDH1A1SMN1; SMN2HIF1A
SCHEMBL7033196 0.79 EGFR (0.31) EGFRERBB2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1064253-B1 ANTI-TUMOUR AGENTS ASTRAZENECA AB (SE) 2003-01-29 EP disclosed
US-6346633-B1 TERT-AMINOPHENYLESTER OF ACID ASTRAZENECA AB (SE) 2002-02-12 US disclosed
EP-1064253-A1 ANTI-TUMOUR AGENTS AstraZeneca AB (SE) 2001-01-03 EP disclosed
WO-1999048857-A1 ANTI-TUMOUR AGENTS ASTRAZENECA AB (SE) 1999-09-30 WO disclosed