Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD3 | P35462 | 7/20 | 0.47 |
| ▸ | DRD2 | P14416 | 6/20 | 0.47 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.46 |
| ▸ | PLAU | P00749 | 1/20 | 0.46 |
| ▸ | HTR6 | P50406 | 2/20 | 0.43 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.41 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.41 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | CXCR4 | P61073 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4788557 | 1.00 | DRD3 (0.47) | DRD3DRD2ADRA2CPLAUHTR6 | |
| SCHEMBL6816574 | 1.00 | DRD3 (0.47) | DRD3DRD2ADRA2CPLAUHTR6 | |
| SCHEMBL7022932 | 0.88 | DRD3 (0.54) | DRD3DRD2ADRA2CPLAUHTR6 | |
| SCHEMBL4210231 | 0.88 | DRD3 (0.54) | DRD3DRD2ADRA2CPLAUHTR6 | |
| SCHEMBL7024133 | 0.88 | DRD3 (0.54) | DRD3DRD2ADRA2CPLAUHTR6 | |
| SCHEMBL7027637 | 0.86 | DRD2 (0.49) | DRD3DRD2HTR6SIGMAR1 | |
| SCHEMBL7027642 | 0.86 | DRD2 (0.49) | DRD3DRD2HTR6SIGMAR1 | |
| SCHEMBL7021581 | 0.84 | DRD2 (0.51) | DRD3DRD2 | |
| SCHEMBL7021575 | 0.84 | DRD2 (0.51) | DRD3DRD2 | |
| SCHEMBL6819421 | 0.84 | PLAU (0.45) | DRD3DRD2PLAUHTR6SIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0888319-B1 | SUBSTITUTED 1,2,3,4-TETRAHYDRONAPHTHALENE DERIVATIVES | ASTRAZENECA AB (SE) | 2003-01-29 | — | — | EP | disclosed |
| US-6410530-B1 | CENTRAL NERVOUS SYSTEM DISORDERS; PSYCHOLOGICAL DISORDERS | ASTRAZENECA AB (SE) | 2002-06-25 | — | — | US | disclosed |
| US-6124283-A | Substituted 1,2,3,4-tetrahydronaphthalene derivatives | ASTRA AKTIEBOLAG (SE) | 2000-09-26 | — | — | US | disclosed |