Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE3B | Q13370 | 8/20 | 0.43 |
| ▸ | PDE3A | Q14432 | 8/20 | 0.43 |
| ▸ | PARP1 | P09874 | 4/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | CA12 | O43570 | 1/20 | 0.42 |
| ▸ | CA9 | Q16790 | 1/20 | 0.42 |
| ▸ | P2RY12 | Q9H244 | 6/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | DRD1 | P21728 | 1/20 | 0.39 |
| ▸ | PDE2A | O00408 | 3/20 | 0.39 |
| ▸ | DRD2 | P14416 | 3/20 | 0.39 |
| ▸ | CTSV | O60911 | 1/20 | 0.39 |
| ▸ | CTSL | P07711 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7031275 | 0.94 | PDE3B (0.43) | PDE3BPDE3APARP1KDM4ECA12 | |
| SCHEMBL7029278 | 0.88 | PDE3B (0.54) | PDE3BPDE3APARP1KDM4ECA12 | |
| SCHEMBL7034389 | 0.88 | KDM4E (0.44) | PDE3BPDE3APARP1KDM4ECA12 | |
| SCHEMBL7031273 | 0.85 | MAPT (0.46) | PDE3BPDE3APARP1KDM4ECA12 | |
| SCHEMBL7037717 | 0.82 | PDE3B (0.54) | PDE3BPDE3APARP1KDM4ECA12 | |
| SCHEMBL7031379 | 0.81 | HSD17B10 (0.61) | PDE3BPDE3APARP1KDM4ECA12 | |
| SCHEMBL30615172 | 0.81 | HSD17B10 (0.61) | PDE3BPDE3APARP1KDM4ECA12 | |
| SCHEMBL7031724 | 0.81 | KDM4E (0.44) | PDE3BPDE3APARP1KDM4ECA12 | |
| SCHEMBL7030050 | 0.78 | MAOA (0.42) | PDE3BPDE3APARP1KDM4ECA12 | |
| SCHEMBL31275105 | 0.76 | KDM4E (0.60) | PDE3BPDE3APARP1KDM4ECA12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0878468-B1 | Process for producing 1-substituted tetrahydroquinazolines | SUMITOMO CHEMICAL CO (JP) | 2003-03-19 | — | — | EP | disclosed |
| EP-0775697-B1 | Process for producing 1-substituted tetrahydroquinazolindionen | SUMITOMO CHEMICAL CO (JP) | 2003-02-12 | — | — | EP | disclosed |
| US-5994542-A | Process for producing 1-substituted tetrahydroquinazolines | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 1999-11-30 | — | — | US | disclosed |
| EP-0878468-A1 | Process for producing 1-substituted tetrahydroquinazolines | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 1998-11-18 | — | — | EP | disclosed |
| US-5756738-A | Process for producing 1-substituted tetrahydroquinazolines | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 1998-05-26 | — | — | US | disclosed |
| EP-0775697-A1 | Process for producing 1-substituted tetrahydroquinazolindionen | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 1997-05-28 | — | — | EP | disclosed |