Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTNR1A | P48039 | 2/20 | 0.48 |
| ▸ | MTNR1B | P49286 | 2/20 | 0.48 |
| ▸ | DRD2 | P14416 | 8/20 | 0.45 |
| ▸ | DRD3 | P35462 | 7/20 | 0.45 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.45 |
| ▸ | SCN9A | Q15858 | 3/20 | 0.45 |
| ▸ | SCN5A | Q14524 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | TSHR | P16473 | 2/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | WDR5 | P61964 | 1/20 | 0.42 |
| ▸ | DRD4 | P21917 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7026958 | 1.00 | MTNR1A (0.48) | MTNR1AMTNR1BDRD2DRD3KCNH2 | |
| SCHEMBL7027946 | 0.91 | KCNH2 (0.52) | MTNR1AMTNR1BDRD2DRD3KCNH2 | |
| SCHEMBL7027944 | 0.91 | KCNH2 (0.52) | MTNR1AMTNR1BDRD2DRD3KCNH2 | |
| SCHEMBL7023930 | 0.87 | NPC1 (0.56) | MTNR1AMTNR1BDRD2KCNH2SCN9A | |
| SCHEMBL7023936 | 0.87 | NPC1 (0.56) | MTNR1AMTNR1BDRD2KCNH2SCN9A | |
| SCHEMBL7026344 | 0.84 | MTNR1A (0.52) | MTNR1AMTNR1BDRD2KCNH2SCN9A | |
| SCHEMBL7026340 | 0.84 | MTNR1A (0.52) | MTNR1AMTNR1BDRD2KCNH2SCN9A | |
| SCHEMBL7027930 | 0.83 | MTNR1A (0.65) | MTNR1AMTNR1BDRD2DRD3KCNH2 | |
| SCHEMBL7027929 | 0.83 | MTNR1A (0.65) | MTNR1AMTNR1BDRD2DRD3KCNH2 | |
| SCHEMBL7029145 | 0.83 | MTNR1A (0.49) | MTNR1AMTNR1BDRD2DRD3KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0888319-B1 | SUBSTITUTED 1,2,3,4-TETRAHYDRONAPHTHALENE DERIVATIVES | ASTRAZENECA AB (SE) | 2003-01-29 | — | — | EP | disclosed |
| US-6410530-B1 | CENTRAL NERVOUS SYSTEM DISORDERS; PSYCHOLOGICAL DISORDERS | ASTRAZENECA AB (SE) | 2002-06-25 | — | — | US | disclosed |
| US-6124283-A | Substituted 1,2,3,4-tetrahydronaphthalene derivatives | ASTRA AKTIEBOLAG (SE) | 2000-09-26 | — | — | US | disclosed |