Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LCK | P06239 | 3/20 | 0.70 |
| ▸ | MKNK1 | Q9BUB5 | 13/20 | 0.67 |
| ▸ | MKNK2 | Q9HBH9 | 11/20 | 0.65 |
| ▸ | CDK2 | P24941 | 1/20 | 0.57 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.52 |
| ▸ | TP53 | P04637 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7020797 | 0.92 | LCK (0.66) | LCKMKNK1MKNK2CDK2 | |
| SCHEMBL7025386 | 0.86 | LCK (0.70) | LCKMKNK1MKNK2ROCK1TP53 | |
| SCHEMBL7022907 | 0.86 | LCK (0.70) | LCKMKNK1MKNK2 | |
| SCHEMBL7020088 | 0.86 | LCK (0.70) | LCKMKNK1MKNK2ROCK1 | |
| SCHEMBL7023275 | 0.85 | LCK (0.69) | LCKMKNK1MKNK2CDK2ROCK1 | |
| SCHEMBL7019862 | 0.83 | LCK (0.82) | LCKMKNK1MKNK2CDK2ROCK1 | |
| SCHEMBL7020384 | 0.83 | LCK (0.64) | LCKMKNK1MKNK2CDK2 | |
| SCHEMBL7660299 | 0.83 | LCK (0.73) | LCKMKNK1MKNK2CDK2 | |
| SCHEMBL7020519 | 0.83 | MKNK1 (0.67) | LCKMKNK1MKNK2 | |
| SCHEMBL7022617 | 0.83 | LCK (1.00) | LCKMKNK1MKNK2ROCK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1206265-B1 | SRC KINASE INHIBITOR COMPOUNDS | MERCK & CO INC (US) | 2003-11-12 | — | — | EP | disclosed |
| US-6498165-B1 | PYRIMIDINE COMPOUNDS; PROPHYLAXIS AND TREATMENT OF SUCH AS IMMUNE DISEASES, HYPERPROLIFERATIVE DISORDERS, CANCER, ANGIOGENSIS, ATHEROSCELEROSIS, GRAFT REJECTION, RHEUMATOID ARTHRITIS, PSORIASIS | MERCK & CO., INC. | 2002-12-24 | — | — | US | disclosed |
| EP-1206265-A4 | SRC KINASE INHIBITOR COMPOUNDS | MERCK & CO INC (US) | 2002-08-07 | — | — | EP | disclosed |
| EP-1206265-A1 | SRC KINASE INHIBITOR COMPOUNDS | Merck & Co., Inc. (US) | 2002-05-22 | — | — | EP | disclosed |
| WO-2001000213-A1 | SRC KINASE INHIBITOR COMPOUNDS | MERCK & CO., INC. (US) | 2001-01-04 | — | — | WO | disclosed |