Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 16/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.39 |
| ▸ | MAPK11 | Q15759 | 3/20 | 0.33 |
| ▸ | MAPK13 | O15264 | 2/20 | 0.33 |
| ▸ | MAPK12 | P53778 | 2/20 | 0.33 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.33 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.33 |
| ▸ | P2RX7 | Q99572 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6669233 | 0.84 | MAPK14 (0.46) | MAPK14KCNH2MAPK11MAPK13MAPK12 | |
| SCHEMBL6667202 | 0.77 | MAPK14 (0.45) | MAPK14KCNH2MAPK11MAPK13MAPK12 | |
| SCHEMBL6666942 | 0.71 | MAPK14 (0.44) | MAPK14MAPK11MAPK13MAPK12CHRM5 | |
| SCHEMBL6667962 | 0.67 | MAPK14 (0.33) | MAPK14KCNH2MAPK11MAPK13MAPK12 | |
| SCHEMBL6672579 | 0.65 | MAPK14 (0.40) | MAPK14MAPK11MAPK13MAPK12 | |
| SCHEMBL6667115 | 0.64 | MAPK14 (0.67) | MAPK14KCNH2MAPK11MAPK13MAPK12 | |
| SCHEMBL6668191 | 0.61 | MAPK14 (0.73) | MAPK14KCNH2MAPK11MAPK13MAPK12 | |
| SCHEMBL6670053 | 0.60 | MAPK14 (0.74) | MAPK14KCNH2MAPK11MAPK13MAPK12 | |
| SCHEMBL6667213 | 0.57 | MAPK14 (1.00) | MAPK14KCNH2MAPK11MAPK13MAPK12 | |
| SCHEMBL6667321 | 0.56 | MAPK14 (0.62) | MAPK14MAPK11MAPK13MAPK12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2002058695-A9 | (HALO-BENZO CARBONYL)HETEROCYCLO FUSED PHENYL P38 KINASE INHIBITING AGENTS | MERCK & CO INC (US) | 2003-09-12 | — | — | WO | disclosed |