Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 12/20 | 0.33 |
| ▸ | MAPK11 | Q15759 | 5/20 | 0.33 |
| ▸ | MAPK13 | O15264 | 4/20 | 0.33 |
| ▸ | MAPK12 | P53778 | 4/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6867452 | 0.85 | MAPK14 (0.36) | MAPK14MAPK11MAPK13MAPK12KCNH2 | |
| SCHEMBL7027463 | 0.67 | MAPK14 (0.40) | MAPK14MAPK11MAPK13MAPK12KCNH2 | |
| SCHEMBL6669233 | 0.58 | MAPK14 (0.46) | MAPK14MAPK11MAPK13MAPK12KCNH2 | |
| SCHEMBL6329137 | 0.54 | P2RX7 (0.38) | MAPK14MAPK11MAPK13MAPK12 | |
| SCHEMBL6329131 | 0.54 | P2RX7 (0.38) | MAPK14MAPK11MAPK13MAPK12 | |
| SCHEMBL24119033 | 0.52 | MAPK14 (0.42) | MAPK14MAPK11MAPK13MAPK12 | |
| SCHEMBL8001537 | 0.51 | PTPN1 (0.39) | — | |
| SCHEMBL23556812 | 0.50 | MAPK14 (0.42) | MAPK14MAPK11MAPK13MAPK12 | |
| SCHEMBL8423045 | 0.49 | CASP1 (0.42) | — | |
| SCHEMBL2238426 | 0.49 | PTGES2 (0.46) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1345603-A4 | (HALO-BENZO CARBONYL)HETEROCYCLO FUSED PHENYL P38 KINASE INHIBITING AGENTS | MERCK & CO INC (US) | 2004-09-08 | — | — | EP | disclosed |
| EP-1345603-A1 | (HALO-BENZO CARBONYL)HETEROCYCLO FUSED PHENYL P38 KINASE INHIBITING AGENTS | Merck & Co., Inc. (US) | 2003-09-24 | — | — | EP | disclosed |
| WO-2002058695-A1 | (HALO-BENZO CARBONYL)HETEROCYCLO FUSED PHENYL P38 KINASE INHIBITING AGENTS | MERCK & CO., INC. (US) | 2002-08-01 | — | — | WO | disclosed |