Citric Acid

Citric Acid

SCHEMBL7028347

O=C(O)CC(O)(CC(=O)O)C(=O)O.OB(O)O.[Na+].[O-]B(O)O

nearest known ligand 0.68

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

ACVR1ADORA1ADORA2AADORA2BADORA3ESR1ESR2FLT3GRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BGSC1HRH1HTR7IDH1IDH2IRAK1JAK1JAK2JAK3MEN1OPRM1P2RX3PDE5ASCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASIGMAR1SLC6A2SYKTACR1TOP2ATYK2

The experimentally established mechanism targets of Citric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MEN1 known ✓ O00255 1/20 0.35
ALDH1A1 P00352 2/20 0.68
HMGCR P04035 1/20 0.37
CHRM1 P11229 1/20 0.37
TBXA2R P21731 1/20 0.37
ADRA1A P35348 1/20 0.37
TSHR P16473 2/20 0.37
KDM4E B2RXH2 2/20 0.37
LMNA P02545 2/20 0.37
MAPT P10636 1/20 0.37
ALOX15 P16050 1/20 0.37
SLC13A5 Q86YT5 6/20 0.36
CYP2D6 P10635 2/20 0.36
CYP2C19 P33261 1/20 0.36
HIF1A Q16665 1/20 0.36
ACLY P53396 3/20 0.35
CYP1A2 P05177 1/20 0.35
KMT2A Q03164 1/20 0.35
CA4 P22748 1/20 0.34
CPT2 P23786 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Citric Acid SCHEMBL31588819 0.98 ALDH1A1 (0.71) ALDH1A1HMGCRCHRM1TBXA2RADRA1A
Citric Acid SCHEMBL4256392 0.91 ALDH1A1 (0.68) ALDH1A1HMGCRCHRM1TBXA2RADRA1A
Citric Acid SCHEMBL4564858 0.91 ALDH1A1 (0.75) ALDH1A1HMGCRCHRM1TBXA2RADRA1A
Citric Acid SCHEMBL1971126 0.91 ALDH1A1 (0.83) ALDH1A1HMGCRCHRM1TBXA2RADRA1A
Citric Acid SCHEMBL7728616 0.90 ALDH1A1 (0.60) ALDH1A1HMGCRCHRM1TBXA2RADRA1A
Citric Acid SCHEMBL27231788 0.88 ALDH1A1 (0.79) ALDH1A1HMGCRCHRM1TBXA2RADRA1A
Citric Acid SCHEMBL4564860 0.88 ALDH1A1 (0.79) ALDH1A1HMGCRCHRM1TBXA2RADRA1A
Citric Acid SCHEMBL27629209 0.87 ALDH1A1 (0.52) ALDH1A1TSHRKDM4ELMNAMAPT
Citric Acid SCHEMBL2236680 0.87 ALDH1A1 (0.62) ALDH1A1HMGCRCHRM1TBXA2RADRA1A
Citric Acid SCHEMBL28709235 0.86 ALDH1A1 (0.75) ALDH1A1HMGCRCHRM1TBXA2RADRA1A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1278819-A1 LIQUID DETERGENT COMPOSITIONS The Procter & Gamble Company (US) 2003-01-29 EP disclosed
WO-2001085887-A1 LIQUID DETERGENT COMPOSITIONS THE PROCTER & GAMBLE COMPANY (US) 2001-11-15 WO disclosed
EP-1124929-A1 BLEACH-CONTAINING DETERGENT COMPOSITION The Procter & Gamble Company (US) 2001-08-22 EP disclosed
EP-1123376-A2 LAUNDRY AND CLEANING COMPOSITIONS THE PROCTER & GAMBLE COMPANY (US) 2001-08-16 EP disclosed
EP-1080168-A2 DETERGENT COMPOSITIONS THE PROCTER & GAMBLE COMPANY (US) 2001-03-07 EP disclosed
WO-2000027968-A1 BLEACH-CONTAINING DETERGENT COMPOSITION THE PROCTER & GAMBLE COMPANY (US) 2000-05-18 WO disclosed
WO-2000002436-A2 DETERGENT COMPOSITIONS THE PROCTER & GAMBLE COMPANY (US) 2000-01-20 WO disclosed
WO-2000002982-A2 LAUNDRY AND CLEANING COMPOSITIONS THE PROCTER & GAMBLE COMPANY (US) 2000-01-20 WO disclosed
EP-0929637-A4 A DETERGENT COMPOSITION COMPRISING CATIONIC AMINES AND LIPASE ENZYMES PROCTER & GAMBLE (US) 2000-01-05 EP disclosed
EP-0929637-A1 A DETERGENT COMPOSITION COMPRISING CATIONIC AMINES AND LIPASE ENZYMES THE PROCTER & GAMBLE COMPANY (US) 1999-07-21 EP disclosed
WO-1998013463-A1 A DETERGENT COMPOSITION COMPRISING CATIONIC AMINES AND LIPASE ENZYMES THE PROCTER & GAMBLE COMPANY (US) 1998-04-02 WO disclosed