Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 4/20 | 0.46 |
| ▸ | APLNR | P35414 | 2/20 | 0.33 |
| ▸ | BRD4 | O60885 | 3/20 | 0.33 |
| ▸ | SGK1 | O00141 | 1/20 | 0.33 |
| ▸ | SMYD3 | Q9H7B4 | 2/20 | 0.32 |
| ▸ | BRPF1 | P55201 | 1/20 | 0.32 |
| ▸ | MAP2K4 | P45985 | 1/20 | 0.32 |
| ▸ | CXCR2 | P25025 | 1/20 | 0.32 |
| ▸ | HTR6 | P50406 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4290113 | 1.00 | HRH3 (0.46) | HRH3APLNRBRD4SGK1SMYD3 | |
| SCHEMBL4290109 | 1.00 | HRH3 (0.46) | HRH3APLNRBRD4SGK1SMYD3 | |
| SCHEMBL4290100 | 1.00 | HRH3 (0.46) | HRH3APLNRBRD4SGK1SMYD3 | |
| SCHEMBL7107835 | 0.80 | HRH3 (0.48) | HRH3BRD4SGK1SMYD3BRPF1 | |
| SCHEMBL7107837 | 0.80 | HRH3 (0.48) | HRH3BRD4SGK1SMYD3BRPF1 | |
| SCHEMBL4288153 | 0.79 | HRH3 (0.40) | HRH3APLNRHTR6 | |
| SCHEMBL4288161 | 0.79 | HRH3 (0.40) | HRH3APLNRHTR6 | |
| SCHEMBL7024371 | 0.79 | HRH3 (0.40) | HRH3APLNRHTR6 | |
| SCHEMBL4288155 | 0.79 | HRH3 (0.40) | HRH3APLNRHTR6 | |
| SCHEMBL4291020 | 0.78 | HRH3 (0.52) | HRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1326863-A2 | OCTAHYDRO-INDOLIZINES AND QUINOLIZINES AND HEXAHYDRO-PYRROLIZINES | Ortho-McNeil Pharmaceutical, Inc. (US) | 2003-07-16 | — | — | EP | disclosed |
| WO-2002024695-A2 | OCTAHYDRO-INDOLIZINES AND QUINOLIZINES AND HEXAHYDRO-PYRROLIZINES | ORTHO MCNEIL PHARMACEUTICAL, INC. (US) | 2002-03-28 | — | — | WO | disclosed |