Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 5/20 | 0.48 |
| ▸ | BRPF1 | P55201 | 2/20 | 0.36 |
| ▸ | UCHL1 | P09936 | 1/20 | 0.35 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.35 |
| ▸ | BRD4 | O60885 | 3/20 | 0.35 |
| ▸ | SMYD3 | Q9H7B4 | 2/20 | 0.34 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.32 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.32 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.32 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.32 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | TP53 | P04637 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | ATM | Q13315 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | SGK1 | O00141 | 1/20 | 0.31 |
| ▸ | BRAF | P15056 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7107837 | 1.00 | HRH3 (0.48) | HRH3BRPF1UCHL1USP30BRD4 | |
| SCHEMBL4290113 | 0.80 | HRH3 (0.46) | HRH3BRPF1BRD4SMYD3SGK1 | |
| SCHEMBL7028987 | 0.80 | HRH3 (0.46) | HRH3BRPF1BRD4SMYD3SGK1 | |
| SCHEMBL4290100 | 0.80 | HRH3 (0.46) | HRH3BRPF1BRD4SMYD3SGK1 | |
| SCHEMBL4290109 | 0.80 | HRH3 (0.46) | HRH3BRPF1BRD4SMYD3SGK1 | |
| SCHEMBL13663365 | 0.80 | HRH3 (0.52) | HRH3ALDH1A1LMNAMAPTSMN1; SMN2 | |
| SCHEMBL4291010 | 0.80 | HRH3 (0.52) | HRH3ALDH1A1LMNAMAPTSMN1; SMN2 | |
| SCHEMBL4291020 | 0.80 | HRH3 (0.52) | HRH3ALDH1A1LMNAMAPTSMN1; SMN2 | |
| SCHEMBL4291017 | 0.80 | HRH3 (0.52) | HRH3ALDH1A1LMNAMAPTSMN1; SMN2 | |
| SCHEMBL4294233 | 0.75 | HRH3 (0.46) | HRH3ALDH1A1LMNATP53MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20030013733-A1 | Octahydro-indolizine and quinolizine and hexahydro-pyrrolizine | ORTHO MCNEIL PHARMACEUTICAL, INC. | 2003-01-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030013733-A1 | Octahydro-indolizine and quinolizine and hexahydro-pyrrolizine | HRH4, HNMT, HRH1 | HRH3 7/4885BRPF1 1414/4885UCHL1 2904/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.