Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.45 |
| ▸ | HSP90AB1 | P08238 | 2/20 | 0.45 |
| ▸ | DPP4 | P27487 | 5/20 | 0.39 |
| ▸ | CNR1 | P21554 | 3/20 | 0.37 |
| ▸ | CNR2 | P34972 | 3/20 | 0.37 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.37 |
| ▸ | CRHR1 | P34998 | 5/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | MAP3K14 | Q99558 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27538173 | 0.84 | MAP3K14 (0.48) | HSP90AA1HSP90AB1DPP4LMNAMAP3K14 | |
| SCHEMBL7852616 | 0.78 | GSK3B (0.47) | HSP90AA1HSP90AB1DPP4CNR1CNR2 | |
| SCHEMBL29438549 | 0.77 | NPSR1 (0.39) | HSP90AA1HSP90AB1HSD11B1CRHR1MAP3K14 | |
| SCHEMBL4975912 | 0.76 | HSP90AA1 (0.36) | HSP90AA1HSP90AB1HSD11B1CRHR1 | |
| SCHEMBL3660492 | 0.76 | CYP3A4 (0.43) | HSP90AA1HSP90AB1LMNACYP3A4 | |
| SCHEMBL3317224 | 0.75 | ALDH1A1 (0.50) | HSP90AA1HSP90AB1HSD11B1CRHR1 | |
| SCHEMBL952939 | 0.74 | HSP90AA1 (0.37) | HSP90AA1HSP90AB1CNR1CNR2HSD11B1 | |
| SCHEMBL31429725 | 0.74 | IDO1 (0.41) | HSP90AA1HSP90AB1CYP3A4 | |
| SCHEMBL13257647 | 0.73 | HSP90AA1 (0.36) | HSP90AA1HSP90AB1DPP4CNR1CNR2 | |
| SCHEMBL4399097 | 0.73 | GSK3B (0.64) | HSP90AA1HSP90AB1DPP4HSD11B1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1317433-A2 | INHIBITORS OF GLYCOGEN SYNTHASE KINASE 3 | CHIRON CORPORATION (US) | 2003-06-11 | — | — | EP | disclosed |
| WO-2002020495-A2 | INHIBITORS OF GLYCOGEN SYNTHASE KINASE 3 | CHIRON CORPORATION (US) | 2002-03-14 | — | — | WO | disclosed |