Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1I2 | O75469 | 3/20 | 0.61 |
| ▸ | KDM4E | B2RXH2 | 8/20 | 0.55 |
| ▸ | CYP2C9 | P11712 | 6/20 | 0.55 |
| ▸ | HSD17B10 | Q99714 | 6/20 | 0.55 |
| ▸ | CYP1A2 | P05177 | 5/20 | 0.55 |
| ▸ | CYP3A4 | P08684 | 5/20 | 0.55 |
| ▸ | CYP2C19 | P33261 | 5/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.55 |
| ▸ | ADORA3 | P0DMS8 | 4/20 | 0.55 |
| ▸ | ABCB11 | O95342 | 4/20 | 0.55 |
| ▸ | TSHR | P16473 | 4/20 | 0.55 |
| ▸ | HIF1A | Q16665 | 3/20 | 0.55 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.55 |
| ▸ | SCN5A | Q14524 | 3/20 | 0.55 |
| ▸ | HPGD | P15428 | 3/20 | 0.55 |
| ▸ | GMNN | O75496 | 2/20 | 0.55 |
| ▸ | LMNA | P02545 | 2/20 | 0.55 |
| ▸ | TP53 | P04637 | 2/20 | 0.55 |
| ▸ | MAPT | P10636 | 2/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7257040 | 0.88 | KDM4E (0.60) | NR1I2KDM4ECYP2C9HSD17B10CYP1A2 | |
| SCHEMBL29676206 | 0.87 | NR1I2 (0.73) | NR1I2KDM4ECYP2C9HSD17B10CYP1A2 | |
| SCHEMBL3034560 | 0.87 | NR1I2 (0.73) | NR1I2KDM4ECYP2C9HSD17B10CYP1A2 | |
| SCHEMBL7414856 | 0.82 | NR1I2 (0.67) | NR1I2KDM4ECYP2C9HSD17B10CYP1A2 | |
| SCHEMBL7025790 | 0.82 | NR1I2 (0.56) | NR1I2KDM4ECYP2C9HSD17B10CYP1A2 | |
| SCHEMBL10367692 | 0.82 | NR1I2 (0.56) | NR1I2KDM4ECYP2C9HSD17B10CYP1A2 | |
| SCHEMBL11450739 | 0.79 | CYP2C9 (0.79) | NR1I2KDM4ECYP2C9HSD17B10CYP1A2 | |
| SCHEMBL10829935 | 0.78 | CYP2C9 (0.66) | NR1I2KDM4ECYP2C9HSD17B10CYP1A2 | |
| SCHEMBL10750223 | 0.77 | NR1I2 (0.60) | NR1I2KDM4ECYP2C9HSD17B10CYP1A2 | |
| SCHEMBL11450756 | 0.77 | CYP2C9 (0.59) | NR1I2KDM4ECYP2C9HSD17B10CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20030230478-A1 | Process for the preparation of 1,4 - dihydropyridines and novel 1,4-dihydropyridines useful as therapeutic agents | COUNCIL OF SCIENTIFIC AND INDUSTRIAL RESEARCH | 2003-12-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030230478-A1 | Process for the preparation of 1,4 - dihydropyridines and novel 1,4-dihydropyridines useful as therapeutic agents | HRH4, ODC1, OGDH | NR1I2 712/4885KDM4E 942/4885CYP2C9 493/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.